{"created":"2023-05-15T14:45:40.194907+00:00","id":62400,"links":{},"metadata":{"_buckets":{"deposit":"2edf5f0a-d7ee-48ef-aada-8557ac987f0a"},"_deposit":{"created_by":1,"id":"62400","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"62400"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00062400","sets":["10:29"]},"author_link":["616736","616731","616733","616730","616739","616737","616734","616741","616735","616738","616728","616732","616740","616729"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2007-11-06","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"PETを用いた抗精神病薬によるドーパミンD２受容体占有率の測定は、抗精神病薬の用量設定に有用である。この測定では、薬物投与前後で大きく異なる受容体結合能(BP)を精度よく測定できることが必要である。本研究では、[11C]racloprideおよび[11C]FLB457を用いたドーパミンD２受容体結合能測定における測定精度を検討した。シミュレーションで抗精神病薬投与前後の疑似PET時間放射能曲線を作成し、simplified reference tissue modelを用いてBPを計算して、ノイズレベルやスキャン時間とBP推定精度の関係を調べた。実測データからもbootstrap法を用いて疑似時間放射能曲線を作成し、同様にBPを求めて実測データにおける測定精度を検討した。ROI解析では、[11C]racloprideでは30分以上、[11C]FLBは60分以上の測定時間があれば、誤差5%以下のBP推定が可能であることが判明した。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第47回日本核医学会学術総会　","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"生駒, 洋子"}],"nameIdentifiers":[{"nameIdentifier":"616728","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 浩"}],"nameIdentifiers":[{"nameIdentifier":"616729","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"志田原, 美保"}],"nameIdentifiers":[{"nameIdentifier":"616730","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関, 千江"}],"nameIdentifiers":[{"nameIdentifier":"616731","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村, 裕一"}],"nameIdentifiers":[{"nameIdentifier":"616732","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"616733","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菅野, 巖"}],"nameIdentifiers":[{"nameIdentifier":"616734","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"生駒 洋子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"616735","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"616736","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"志田原 美保","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"616737","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関 千江","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"616738","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村 裕一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"616739","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"616740","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菅野 巖","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"616741","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"PETを用いた脳内ドーパミンD2受容体の占有率測定における精度評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"PETを用いた脳内ドーパミンD2受容体の占有率測定における精度評価"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-01-22"},"publish_date":"2008-01-22","publish_status":"0","recid":"62400","relation_version_is_last":true,"title":["PETを用いた脳内ドーパミンD2受容体の占有率測定における精度評価"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:31:12.644386+00:00"}