{"created":"2023-05-15T14:45:35.564735+00:00","id":62296,"links":{},"metadata":{"_buckets":{"deposit":"96e67079-cb0c-43ce-be51-220e188c8ae2"},"_deposit":{"created_by":1,"id":"62296","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"62296"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00062296","sets":["10:29"]},"author_link":["615756","615759","615748","615757","615751","615750","615758","615752","615753","615755","615749","615754"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2007-11-06","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"PETを用いた抗精神病薬によるドーパミンD２受容体占有率の測定は、抗精神病薬の用量設定に有用である。この測定では、薬物投与前後で大きく異なる受容体結合能(BP)を精度よく測定できることが必要である。本研究では、[11C]racloprideおよび[11C]FLB457を用いたドーパミンD２受容体結合能測定における測定精度を検討した。シミュレーションで抗精神病薬投与前後の疑似PET時間放射能曲線を作成し、simplified reference tissue modelを用いてBPを計算して、ノイズレベルやスキャン時間とBP推定精度の関係を調べた。実測データからもbootstrap法を用いて疑似時間放射能曲線を作成し、同様にBPを求めて実測データにおける測定精度を検討した。ROI解析では、[11C]racloprideでは30分以上、[11C]FLBは60分以上の測定時間があれば、誤差5%以下のBP推定が可能であることが判明した。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第４７回　日本核医学会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"生駒, 洋子"}],"nameIdentifiers":[{"nameIdentifier":"615748","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"志田原, 美保"}],"nameIdentifiers":[{"nameIdentifier":"615749","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関, 千江"}],"nameIdentifiers":[{"nameIdentifier":"615750","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村, 裕一"}],"nameIdentifiers":[{"nameIdentifier":"615751","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"615752","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菅野, 巖"}],"nameIdentifiers":[{"nameIdentifier":"615753","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"生駒 洋子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"615754","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"志田原 美保","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"615755","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"関 千江","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"615756","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村 裕一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"615757","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"615758","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菅野 巖","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"615759","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"PETを用いた脳内ドーパミンD2受容体D2受容体の占有立測定における精度評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"PETを用いた脳内ドーパミンD2受容体D2受容体の占有立測定における精度評価"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-11-08"},"publish_date":"2007-11-08","publish_status":"0","recid":"62296","relation_version_is_last":true,"title":["PETを用いた脳内ドーパミンD2受容体D2受容体の占有立測定における精度評価"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:32:23.850647+00:00"}