{"created":"2023-05-15T14:45:34.631306+00:00","id":62275,"links":{},"metadata":{"_buckets":{"deposit":"f830b0ee-92d0-4686-8f2c-a9e3c0bc9669"},"_deposit":{"created_by":1,"id":"62275","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"62275"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00062275","sets":["10:29"]},"author_link":["615522","615525","615526","615527","615521","615524","615523","615520"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2007-11-06","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"背景：脳内ドーパミン（DA）放出はニコチンにより促進され、ニコチンの依存形成に\n関わっている。racloprideがシナプスのDAと競合的にDAD2受容体に結合することより\n、喫煙者では喫煙後、線条体の[11C]racloprideのbinding potential (BP)が低下し\nたという報告があるが、非喫煙者との比較は検討されていない。本研究ではニコチン\n負荷によるDA放出を喫煙者・非喫煙者両群で比較・検討した。方法：喫煙者6人、非\n喫煙者6人を対象に2回の[11C]raclopride PETを行い、各PETスキャン開始1時間前よ\nりニコチンガム（N）かプラセボガム（P）を投与した。N、P各条件下での線条体（被\n殻、尾状核）のBPを比較した。結果：喫煙者ではPと比べてNで被殻、尾状核のBPの有\n意な低下を認めたが、非喫煙者では認めなかった。喫煙者の線条体のBPの低下とニコ\nチン依存度に正の相関がみられた。結論：喫煙者ではニコチン負荷によるDA放出が亢\n進していることが示唆された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第47回日本核医学会学術総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高橋, 英彦"}],"nameIdentifiers":[{"nameIdentifier":"615520","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野, 晴成"}],"nameIdentifiers":[{"nameIdentifier":"615521","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 浩"}],"nameIdentifiers":[{"nameIdentifier":"615522","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"615523","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高橋 英彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"615524","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高野 晴成","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"615525","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 浩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"615526","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"615527","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"ニコチン負荷による線条体におけるドーパミン放出とニコチン依存度の関係","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ニコチン負荷による線条体におけるドーパミン放出とニコチン依存度の関係"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-11-06"},"publish_date":"2007-11-06","publish_status":"0","recid":"62275","relation_version_is_last":true,"title":["ニコチン負荷による線条体におけるドーパミン放出とニコチン依存度の関係"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:32:37.879676+00:00"}