{"created":"2023-05-15T14:45:26.275919+00:00","id":62088,"links":{},"metadata":{"_buckets":{"deposit":"4c5cd017-623e-402a-a0de-7cbbec217018"},"_deposit":{"created_by":1,"id":"62088","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"62088"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00062088","sets":["10:29"]},"author_link":["614025","614009","614013","614014","614017","614004","614003","614016","614021","613999","614008","614019","614000","614015","614022","614002","614005","614024","614010","614020","614011","614012","614006","614023","614018","614001","614007"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2006-07-01","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【背景と目的】我々は、1995年以来、食道癌術前重粒子線照射の検討を行っている。現在、21世紀COEプログラム研究の一環として、T1b-T3症例を対象として、新たな臨床試験が進行中である。これまでに3例で組織学局所効果grade3が認められたので報告する。【症例】[症例1]症例：69才、男性。主訴：特になし。現病歴：2004年7月、検診の上部消化管内視鏡検査で食道に0-IIc+Ipl+Ip病変を認め、生検で扁平上皮癌（以後SCC)であった。精査にてT1bN0M0,stageIであった。2004年10月、重粒子線治療を1回3.6GyE,全8回、総線量28.8GyEを2週間で行った。[症例2]症例:64才、男性。主訴：特になし。現病歴：2004年10月、検診の上部消化管内視鏡検査で食道に0-IIc病変を認め、生検でSCCを認めた。精査にてT1bN0M0,stageIであった。2004年12月から2005年1月まで、重粒子線治療を1回3.8GyE,全8回、総線量30.4GyEを2週間で行った。[症例3]症例：71才、男性。主訴：食道のつかえ感、しみる感じ。現病歴：2005年3月、主訴が出現し、近医を受診した。上部消化管内視鏡検査で食道に3型腫瘍を認め、生検でSCCであった。精査にてT2N0M0,stageIIであった。2005年5月、重粒子線治療を1回4.0GyE,全８回、総線量32.0GyEを２週間で行った。これら３例は、重粒子線照射終了１ヵ月後に右開胸開腹胸部食道全摘後縦隔経路胃管再建術、頚部リンパ節郭清を施行している。病理学的検査で３例とも局所腫瘍細胞の残存を認めなかったが、症例2において照射野外のリンパ節において、101Rに１個、104Rに１個、106recRに２個の転移を認めた。現在、明らかな再発を認めていない。\n【結語と考察】術前重粒子線照射を施行した13例中3例で組織学局所効果grade3を認めた。線量増量試験進行中であるため照射線量は、28.8-32GyEと低線量単独治療であるが、良好な局所効果が得られている。今後、線量を増加してゆくとともに、長期予後ならびに長期有害事象を解析する予定である。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第60回日本食道学会学術集会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"成島, 一夫"}],"nameIdentifiers":[{"nameIdentifier":"613999","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田, 英昭"}],"nameIdentifiers":[{"nameIdentifier":"614000","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"阿久津, 泰典"}],"nameIdentifiers":[{"nameIdentifier":"614001","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松原, 久裕"}],"nameIdentifiers":[{"nameIdentifier":"614002","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡住, 慎一"}],"nameIdentifiers":[{"nameIdentifier":"614003","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鍋谷, 圭宏"}],"nameIdentifiers":[{"nameIdentifier":"614004","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"北林, 宏之"}],"nameIdentifiers":[{"nameIdentifier":"614005","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安田, 茂雄"}],"nameIdentifiers":[{"nameIdentifier":"614006","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田, 滋"}],"nameIdentifiers":[{"nameIdentifier":"614007","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田, 正"}],"nameIdentifiers":[{"nameIdentifier":"614008","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉川, 京燦"}],"nameIdentifiers":[{"nameIdentifier":"614009","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻井, 博彦"}],"nameIdentifiers":[{"nameIdentifier":"614010","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"落合, 武徳"}],"nameIdentifiers":[{"nameIdentifier":"614011","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"その他"}],"nameIdentifiers":[{"nameIdentifier":"614012","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"成島 一夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"614013","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 英昭","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"614014","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"阿久津 泰典","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"614015","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松原 久裕","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"614016","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡住 慎一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"614017","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鍋谷 圭宏","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"614018","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"北林 宏之","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"614019","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安田 茂雄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"614020","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田 滋","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"614021","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田 正","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"614022","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉川 京燦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"614023","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻井 博彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"614024","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"落合 武徳","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"614025","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference 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