{"created":"2023-05-15T14:45:19.956920+00:00","id":61947,"links":{},"metadata":{"_buckets":{"deposit":"6f32e0bd-acd5-49ce-bf95-35a1bc7a9bc0"},"_deposit":{"created_by":1,"id":"61947","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"61947"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00061947","sets":["10:29"]},"author_link":["613002","613005","613003","613001","612998","613000","613006","612995","612996","613004","612999","612997"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2006-11-28","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"From 1994 to 1999, we conducted a phase I/II clinical trial for stage I non-small cell lung cancer (NSCLC) by using carbon ion beams alone, demonstrating optimal doses of 90 GyE in 18 fractions over 6 weeks and 72 GyE in 9 fractions over 3 weeks for achieving more than 95% local control with minimal pulmonary damage. In the present study, the total dose was fixed at 72 GyE in 9 fractions over 3 weeks, and at 52.8 GyE for stage IA and 60 GyE for stage 1B in 4 fractions over 1 week. Following this schedule, we conducted a phase II clinical trial for stage I NSCLC from 1999 to 2003. Most targets were irradiated from four oblique directions. A respiratory-gated irradiation system was used for all sessions. Local control and survival were assessed by the Kaplan-Meier method. For statistical testing, the long-rank test was used.\nThe local control rate for all patients was 91.5%, and those for T1 and T2 tumors were 96.3% and 84.7%, respectively. While there was significant difference (p=0.0156) in tumor control rate between T1 and T2, there was no significant difference (P=0.1516) between squamous and non-squamous. The five-year cause-specific survival rate was 67.0% (IA: 84.4, IB: 43.7), and overall survival was 45.3% (IA: 53.9, 1B: 34.2). No adverse effects greater than grade 3 occurred in the lung. Carbon beam radiotherapy, an excellent new modality in terms of high QOL and ADL, was proven to be a valid alternative to surgery for stage I cancer, especially for elderly and inoperable patients.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"NIRS-CNAO Joint Symposium on Carbon Ion Radiotherapy","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Miyamoto, Tadaaki"}],"nameIdentifiers":[{"nameIdentifier":"612995","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Baba, Masayuki"}],"nameIdentifiers":[{"nameIdentifier":"612996","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yashiro, Tomoyasu"}],"nameIdentifiers":[{"nameIdentifier":"612997","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sugane, Toshio"}],"nameIdentifiers":[{"nameIdentifier":"612998","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakajima, Mio"}],"nameIdentifiers":[{"nameIdentifier":"612999","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsujii, Hirohiko"}],"nameIdentifiers":[{"nameIdentifier":"613000","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宮本 忠昭","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"613001","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"馬場 雅行","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"613002","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"矢代 智康","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"613003","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須金 紀雄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"613004","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中嶋 美緒","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"613005","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻井 博彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"613006","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Carbon Ion Radiotherapy in Hypofraction Regimen for Stage I Non-Small Cell Lung Cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Carbon Ion Radiotherapy in Hypofraction Regimen for Stage I Non-Small Cell Lung Cancer"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-12-07"},"publish_date":"2006-12-07","publish_status":"0","recid":"61947","relation_version_is_last":true,"title":["Carbon Ion Radiotherapy in Hypofraction Regimen for Stage I Non-Small Cell Lung Cancer"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:36:27.187642+00:00"}