@misc{oai:repo.qst.go.jp:00061928,
 author = {Tsuji, Hiroshi and Hirasawa, Naoki and Kato, Hiroyuki and Nomiya, Takuma and Yanagi, Takeshi and Kamada, Tadashi and Mizoe, Junetsu and Kanai, Tatsuaki and Tsujii, Hirohiko and 辻 比呂志 and 平澤 直樹 and 加藤 弘之 and 野宮 琢磨 and 柳 剛 and 鎌田 正 and 溝江 純悦 and 金井 達明 and 辻井 博彦},
 month = {Nov},
 note = {Purpose: Analysis on the results of hypofractionated conformal carbon ion radiotherapy (C-ion RT) for localized prostate cancer was performed, with special regard to normal tissue morbidity, biochemical relapse-free rate (bNED), and patient survival.
Methods and Materials: Three hundreds and seventy-four prostate cancer patients who received C-ion RT established through two preceding dose-escalation studies were analyzed in regard to toxicity, survival, and bNED.
Results: Concerning radiation morbidity, no grade 3 or higher toxicities were observed either in the rectum or genitourinary system (GU), and the incidences of grade 2 rectum and GU morbidity were only 1.9% and 6.8%, respectively. Overall bNED at 5 years was 88.35, with only two local recurrences. Gleason's score and T-stage were significant prognostic factors for bNED, but initial PSA showed no definitive influence on bNED. The duration of hormonal therapy also had a strong impact on biochemical control in high-risk patients, but it appeared possible to apply C-ion RT with short-course hormonal therapy to intermediate-risk patients.
Conclusion: C-ion RT with the established dose fractionation regimen yielded satisfactory bNED with only two local recurrences, and with minimal morbidity., NIRS-CNAO Joint Symposium on Carbon Ion Radiotherapy},
 title = {Carbon Ion Radiotherapy for Prostate Cancer},
 year = {2006}
}