{"created":"2023-05-15T14:45:09.189322+00:00","id":61704,"links":{},"metadata":{"_buckets":{"deposit":"f35e1ae2-3d88-4cd5-b395-39bae8b1c0d2"},"_deposit":{"created_by":1,"id":"61704","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"61704"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00061704","sets":["10:29"]},"author_link":["610882","610875","610876","610880","610877","610873","610878","610874","610872","610881","610879"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2004-11-27","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ScidマウスはDNA-PKcsの自然突然変異を持ち、DNA二本鎖切断修復活性が低く放射線感受性であって、放射線照射によって高率に胸腺リンパ腫を発生する。生後８週で0.05から3Gyのγ線一回照射で、scidマウスの胸腺リンパ腫発生線量効果関係を得た。0.1Gy以下では自然発生率（35.5％）と比較して有意差がなかったが、0.25Gy以上で有意に腫瘍発生が増加し、2Gyで80.6％まで増加した。線量効果曲線においては二次多項式がよくあてはまった。野生型C.B-17マウスでは1Gy以下で有意な胸腺リンパ腫発生は認められず、5Gyで最大値12.5％であった。DNA-PKcsはさまざまな臓器の放射線障害修復反応に関与しているので、種々の放射線誘発腫瘍発生が期待される。1-3Gyの範囲でscid homozygotes、 同heterozygotes、野生型マウスについて発癌スペクトラムをしらべ、組織学的検索を行なった。カプラン・マイヤー法による統計的解析の結果、照射依存的に発生した胸腺リンパ腫、卵巣顆粒膜細胞腫、肝上皮性細胞腫、肺腺癌のうち、scidマウスに特異的なものは胸腺リンパ腫のみであった。これらの胸腺リンパ腫以外の放射線依存性腫瘍発生にはDNA-PKcs欠失は関与しない結果を得た。Scidマウスについて、癌遺伝子Notch1 の変異がある胸腺リンパ腫の割合は線量によらずほぼ53-73％であって、Notch1 は胸腺リンパ腫発生に関与する重要な遺伝子のひとつであった。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第４７回日本放射線影響学会大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石井, 洋子"}],"nameIdentifiers":[{"nameIdentifier":"610872","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小林, 森"}],"nameIdentifiers":[{"nameIdentifier":"610873","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村, まゆみ"}],"nameIdentifiers":[{"nameIdentifier":"610874","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田, 義也"}],"nameIdentifiers":[{"nameIdentifier":"610875","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荻生, 俊昭"}],"nameIdentifiers":[{"nameIdentifier":"610876","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻, 秀雄"}],"nameIdentifiers":[{"nameIdentifier":"610877","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石井 洋子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"610878","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 まゆみ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"610879","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 義也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"610880","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荻生 俊昭","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"610881","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻 秀雄","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"610882","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Scidマウスにおける放射線誘発胸腺リンパ腫の線量効果関係","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Scidマウスにおける放射線誘発胸腺リンパ腫の線量効果関係"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-08-03"},"publish_date":"2006-08-03","publish_status":"0","recid":"61704","relation_version_is_last":true,"title":["Scidマウスにおける放射線誘発胸腺リンパ腫の線量効果関係"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:39:16.722114+00:00"}