{"created":"2023-05-15T14:45:03.940706+00:00","id":61586,"links":{},"metadata":{"_buckets":{"deposit":"5f9a27b1-9048-40f7-a5de-0e217a447b5c"},"_deposit":{"created_by":1,"id":"61586","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"61586"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00061586","sets":["10:29"]},"author_link":["609499","609494","609507","609492","609504","609503","609493","609506","609496","609500","609509","609497","609498","609501","609505","609491","609502","609508","609495"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2004-11-06","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"６５歳以上で発症した晩発性アルツハイマー病（LOAD）１５例と、６５歳未満で発症した早発性アルツハイマー病（EOAD）１５例を対象に〔11Ｃ〕-N-メチルピペリジン-４-アセテート（〔11Ｃ〕MP４A）ＰＥＴを撮像し、両群の脳内アセチルコリンエステラーゼ（AChE）活性の相違について比較検討した。ROI法を用いた解析に拠れば、AChE活性の健常対象群（NC）に対する低下率は、大脳新皮質全般に於いてEOAD（平均-22.0％）がLOAD（-16.7％）よりも有意に高度であったのに対して、側頭葉内側面に於いては逆にLOADの低下率がEOADの低下率を凌駕する傾向が認められた。この結果を踏まえ、今回はSPM2を用いて空間的標準化を施しピクセルレベルでの統計学的検討を試みた。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第44回日本核医学会総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"黄田, 常嘉"}],"nameIdentifiers":[{"nameIdentifier":"609491","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠, 仁"}],"nameIdentifiers":[{"nameIdentifier":"609492","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福士, 清"}],"nameIdentifiers":[{"nameIdentifier":"609493","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中, 典子"}],"nameIdentifiers":[{"nameIdentifier":"609494","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤, 康一"}],"nameIdentifiers":[{"nameIdentifier":"609495","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"白石, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"609496","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野, 成樹"}],"nameIdentifiers":[{"nameIdentifier":"609497","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"新井, 平伊"}],"nameIdentifiers":[{"nameIdentifier":"609498","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"棚田, 修二"}],"nameIdentifiers":[{"nameIdentifier":"609499","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江, 俊章"}],"nameIdentifiers":[{"nameIdentifier":"609500","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"黄田 常嘉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"609501","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠 仁","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"609502","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福士 清","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"609503","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 典子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"609504","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤 康一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"609505","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"白石 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"609506","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野 成樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"609507","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"棚田 修二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"609508","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江 俊章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"609509","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"早発性および晩発性アルツハイマー病脳内アセチルコリンエステラーゼ活性の比較検討（第2報）","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"早発性および晩発性アルツハイマー病脳内アセチルコリンエステラーゼ活性の比較検討（第2報）"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-07-04"},"publish_date":"2006-07-04","publish_status":"0","recid":"61586","relation_version_is_last":true,"title":["早発性および晩発性アルツハイマー病脳内アセチルコリンエステラーゼ活性の比較検討（第2報）"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:40:40.610117+00:00"}