{"created":"2023-05-15T14:45:03.896518+00:00","id":61585,"links":{},"metadata":{"_buckets":{"deposit":"3a5dfeaa-5bb7-4fd1-ba90-9c5c8585adf3"},"_deposit":{"created_by":1,"id":"61585","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"61585"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00061585","sets":["10:29"]},"author_link":["609487","609490","609476","609479","609481","609482","609480","609483","609486","609489","609478","609485","609475","609474","609484","609488","609477","609473"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2004-11-06","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"軽度認知機能障害（MCI）は年に12−15％はAlzheimer病に移行し、多くはAlzheimer病の前駆状態であると考えられている。我々はMCI9例（男性５例、女性４例、76＋３歳）、健常対照17名（男性11例、女性６例、52±14歳）を対照として〔11Ｃ〕MP4A−PETを施行し、脳内アセチルコリンエステラーゼ（AChE）の変化をSPM2にて解析した。PET画像には16ｍｍの平滑化を行い、小脳をreference tissueとしてHerholz法にてｋ３値を画素ごとに算出し、SPM２を用いて健常対照群とMCI群との間でStudent‐t検定を行った。その結果、ＭＣＩ群の帯状回後部、後頭葉内側において健常対照比較して有意の低下（uncorrectedp＜0.005、extent　50以上）がみられた。MCIにおいて脳内コリン神経系の低下があることが示された。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第44回日本核医学会総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田中, 典子"}],"nameIdentifiers":[{"nameIdentifier":"609473","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠, 仁"}],"nameIdentifiers":[{"nameIdentifier":"609474","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福士, 清"}],"nameIdentifiers":[{"nameIdentifier":"609475","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"黄田, 常嘉"}],"nameIdentifiers":[{"nameIdentifier":"609476","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤, 康一"}],"nameIdentifiers":[{"nameIdentifier":"609477","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"白石, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"609478","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野, 成樹"}],"nameIdentifiers":[{"nameIdentifier":"609479","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"棚田, 修二"}],"nameIdentifiers":[{"nameIdentifier":"609480","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江, 俊章"}],"nameIdentifiers":[{"nameIdentifier":"609481","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 典子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"609482","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠 仁","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"609483","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福士 清","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"609484","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"黄田 常嘉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"609485","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤 康一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"609486","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"白石 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"609487","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野 成樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"609488","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"棚田 修二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"609489","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江 俊章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"609490","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"ＭＰ４Ａ-ＰＥＴ　統計画像解析によるＭＣＩの検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ＭＰ４Ａ-ＰＥＴ　統計画像解析によるＭＣＩの検討"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-07-04"},"publish_date":"2006-07-04","publish_status":"0","recid":"61585","relation_version_is_last":true,"title":["ＭＰ４Ａ-ＰＥＴ　統計画像解析によるＭＣＩの検討"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:40:41.273711+00:00"}