{"created":"2023-05-15T14:44:59.265619+00:00","id":61482,"links":{},"metadata":{"_buckets":{"deposit":"38ac225b-22a3-4eee-865f-2bc2a37593f3"},"_deposit":{"created_by":1,"id":"61482","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"61482"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00061482","sets":["10:29"]},"author_link":["608333","608348","608343","608346","608341","608350","608340","608330","608334","608335","608347","608331","608345","608342","608337","608336","608344","608351","608332","608339","608349","608338"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2004-11-06","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"アルツハイマー病（AD）では脳内のブチリルコリンエステラーゼ（BuChE）活性が増加することが知られている。我々は代謝変換捕捉原理による脳内ＢｕＣｈＥ活性測定用トレーサを開発し、ＰＥＴによるヒト脳内ＢｕＣｈＥ活性測定を試みた。用いたトレーサは〔11Ｃ〕5Ｒ3Ｂと〔11Ｃ〕MP3Bである。対象健常成人３名（57歳から66歳、男性１名、女性２名）である。〔11Ｃ〕5Ｒ3Ｂを1名に、〔11Ｃ〕MP3Bを２名に、それぞれ465から736MBｑ静脈投与し、EXACT47にて経時的脳内放射能を60分間測定し、また静脈採血して血漿中総放射能および未変化体の放射能を測定した。〔11C〕5Ｒ3Ｂ、あたは〔11Ｃ〕MP3Bともに、脳内放射能集積が著しく低く、脳内BuChE活性の測定は不能であった。肺などの抹消臓器によって両放射性薬剤ともに急速に分解され、脳に十分な量が到達できないためと考えられた。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第44回日本核医学会総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"篠遠, 仁"}],"nameIdentifiers":[{"nameIdentifier":"608330","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菊池, 達矢"}],"nameIdentifiers":[{"nameIdentifier":"608331","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福士, 清"}],"nameIdentifiers":[{"nameIdentifier":"608332","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中, 典子"}],"nameIdentifiers":[{"nameIdentifier":"608333","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"黄田, 常嘉"}],"nameIdentifiers":[{"nameIdentifier":"608334","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤, 康一"}],"nameIdentifiers":[{"nameIdentifier":"608335","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"白石, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"608336","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野, 成樹"}],"nameIdentifiers":[{"nameIdentifier":"608337","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"棚田, 修二"}],"nameIdentifiers":[{"nameIdentifier":"608338","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木, 和年"}],"nameIdentifiers":[{"nameIdentifier":"608339","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江, 俊章"}],"nameIdentifiers":[{"nameIdentifier":"608340","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"篠遠 仁","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"608341","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菊池 達矢","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"608342","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福士 清","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"608343","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 典子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"608344","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"黄田 常嘉","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"608345","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤 康一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"608346","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"白石 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"608347","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野 成樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"608348","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"棚田 修二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"608349","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 和年","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"608350","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"入江 俊章","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"608351","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"ＰＥＴによる脳内ＢｕＣｈＥ活性測定の試み","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ＰＥＴによる脳内ＢｕＣｈＥ活性測定の試み"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-06-13"},"publish_date":"2006-06-13","publish_status":"0","recid":"61482","relation_version_is_last":true,"title":["ＰＥＴによる脳内ＢｕＣｈＥ活性測定の試み"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:41:55.031284+00:00"}