{"created":"2023-05-15T14:44:38.416997+00:00","id":61026,"links":{},"metadata":{"_buckets":{"deposit":"d5b1e5b7-b3cf-4e81-86ae-225f4cf41990"},"_deposit":{"created_by":1,"id":"61026","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"61026"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00061026","sets":["10:29"]},"author_link":["604819","604818","604821","604825","604831","604830","604816","604812","604811","604815","604835","604828","604827","604840","604824","604814","604836","604817","604822","604829","604832","604820","604837","604839","604833","604823","604813","604834","604838","604826"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2004-10-30","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"During the course of studying the genetic determinants of normal tissue injury after radiotherapy of cancer patients, we have detected positive correlation of some intronic SNPs on human DNA ligase I locus of chromosome 19 to the severity of the injury.  The human DNA ligase I gene has three consecutive GT-repeat sequences franked by the same polypurine-rich sequence at a place very close to the exon-intron boundary of an alternatively spliced intron.  In this study, we have analyzed stability of the GT-repeat sequences among individuals and haplotype structure surrounding this locus.\nThe genomic region containing the above sequences were amplified from the blood DNA of 9 cancer patients by PCR and cloned into TA-cloning vector.  Plasmid DNAs from 6 independent colonies of each transformant were purified and sequenced, respectively.  We observed variations of the all three GT-repeats among cancer patients and also among the clones from each individual.  Haplotype structure of the 4 SNPs that surround the GT-repeat sequences was estimated using the EM algorism.  The nine cancer individuals were divided into 3 groups according to the above estimated haplotypes.  By comparing the haplotype structure and the GT-repeat sequences, we found that the GT-repeat sequence that located closest to the exon-intron boundary seemed to have solid threshold range in variation for each haplotype.\nFunctional relevance of the human DNA ligase I gene haplotype with different threshold range in length variation of GT-repeat sequence, in a sense related to the individual's radiation sensitivity, will be elucidated in further study.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"ASHG Meeting 2004","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Michikawa, Yuichi"}],"nameIdentifiers":[{"nameIdentifier":"604811","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suga, Tomo"}],"nameIdentifiers":[{"nameIdentifier":"604812","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kouda, Masakazu"}],"nameIdentifiers":[{"nameIdentifier":"604813","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ootsuka, Yoshimi"}],"nameIdentifiers":[{"nameIdentifier":"604814","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Hideyuki"}],"nameIdentifiers":[{"nameIdentifier":"604815","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saegusa, Kumiko"}],"nameIdentifiers":[{"nameIdentifier":"604816","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furuno, Aki"}],"nameIdentifiers":[{"nameIdentifier":"604817","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishikawa, Ken-ichi"}],"nameIdentifiers":[{"nameIdentifier":"604818","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishikawa, Atsuko"}],"nameIdentifiers":[{"nameIdentifier":"604819","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawai, Seiko"}],"nameIdentifiers":[{"nameIdentifier":"604820","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuji, Atsushi"}],"nameIdentifiers":[{"nameIdentifier":"604821","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sugyou, Aya"}],"nameIdentifiers":[{"nameIdentifier":"604822","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Noda, Shuhei"}],"nameIdentifiers":[{"nameIdentifier":"604823","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iwakawa, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"604824","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imai, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"604825","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"道川 祐市","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"604826","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菅 智","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"604827","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"神田 将和","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"604828","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荘司 好美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"604829","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 英幸","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"604830","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"三枝 公美子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"604831","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古野 亜紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"604832","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石川 顕一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"604833","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石川 敦子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"604834","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"川井 聖子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"604835","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻 厚至","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"604836","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須尭 綾","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"604837","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野田 秀平","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"604838","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩川 眞由美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"604839","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井 高志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"604840","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Variation of GT-repeat numbers associated with haplotype structure of human DNA ligase I locus","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Variation of GT-repeat numbers associated with haplotype structure of human DNA ligase I locus"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2005-07-07"},"publish_date":"2005-07-07","publish_status":"0","recid":"61026","relation_version_is_last":true,"title":["Variation of GT-repeat numbers associated with haplotype structure of human DNA ligase I locus"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:47:03.751890+00:00"}