@misc{oai:repo.qst.go.jp:00060991, author = {宮本, 忠昭 and 石井, 幸子 and 小藤, 昌志 and 今井, 礼子 and 古野, 亜紀 and 三枝, 公美子 and 今井, 高志 and 宮本 忠昭 and 石井 幸子 and 小藤 昌志 and 今井 礼子 and 古野 亜紀 and 三枝 公美子 and 今井 高志}, month = {Apr}, note = {Using cultured and nude mouse tumor cell (IA) derived frome a human lung cancer, we studied their radiosensitivity by focusing attention on the dynamics of tumor clonogens. The movement of clonogens in the regrowing IA tumor after X rays irradiation can be divided into three phases: first,: the early and rapid survival recovery(PLD repair) phase, second, the delay phase involving a certain lag in survival change, and third, the repopulation phase consisting of two stagea. Now we compare with the dynamics of tumor clonogens before or after exposure to X rays and carbon-ion beams. PLD repair was not observed in a carbon-ion beam. In relation to radiosensitivity and repair mechanism, we studied the gene expression of the cultured cell and nude tumor with a microarray method using 22K custom oligoallele., 重粒子線がん治療装置等共同利用研究成果発表会}, title = {重粒子線治療における肺癌腫瘍の至適分割法の研究:低酸素下加速分裂細胞の放射線感受性と血管誘導および低酸素関連遺伝子発現について}, year = {2005} }