@misc{oai:repo.qst.go.jp:00060934,
 author = {Bing, Wang and Nenoi, Mitsuru and Yoshida, Mitsuaki and Hayata, Isamu and 王 冰 and 根井 充 and 吉田 光明 and 早田 勇},
 month = {Aug},
 note = {Studies on adaptive response have been of great concern for both public health and academic research, which could bring significant insight into the biological defense mechanisms and offer critical scientific basis for radiation risk estimation and protection. In a series of our recent studies, the existence of radiation-induced adaptive response was revealed in late organogenesis in mice. Characterization of the essential conditions for the successful induction indicated that this phenomenon was due to a complex interplay between dose, dose rate, mouse strain, fetal developmental stage, and mouse gene background.
     Since the discovery of radiation-induced adaptive response by a cytogenetic study on chromosome aberrations in vitro, investigations to date have completed a large amount of cytogenetic data. However, for most of the reports claimed as the in vivo cytogenetic work, the challenging irradiation was usually performed in vitro to the collected cells that were exposed to a low dose or a priming irradiation in vivo. Such studies could only verify if these cells were capable of bringing into an adaptive response in vitro when receiving a challenging irradiation. Thus these studies are not actually in vivo works in the strict sense of the word. In fact in the last one and half decades, little has been done in the cytogenetic studies in vivo. In addition, most of these rare data were published in non-English language journals, which made the limited information even hard to be accessed to. No cytogenetic data are available on the acute changes in fetuses and late consequences in mammalians survived a challenging high dose of prenatal irradiation by virtue of an adaptive response.
     In the coming Crossover Research Project, a cytogenetic study both on prenatal mice irradiated with/without conditions to induce the adaptive response using fetal hepatocytes, and on postnatal survival mice using splenocytes, will be carried out. This study would provide some basic cytogenetic data on in vivo adaptive response in fetal mice. The cytogenetic data on the early chromosome damage and their timely progress from the fetal mice could contribute important information to possible differences in the occurrences of chromosome damage between the adapted animals and the non-adapted animals, and possible differences in the repair of chromosome damage in the finally survived animals as well. The postnatal cytogenetic data could also be of interest to comprehensively evaluate the life quality as well as to make risk estimation for the animals survived the lethal irradiation by the adaptive response., International Workshop on Biological Responses to Low Dose Radiation},
 title = {Radiation-Induced Adaptive Response in Late Organogenesis in Mice: A Prenatal and Postnatal Cytogenetic Study},
 year = {2004}
}