{"created":"2023-05-15T14:44:29.480410+00:00","id":60826,"links":{},"metadata":{"_buckets":{"deposit":"290f181e-a4e2-467b-998e-750c12aadf00"},"_deposit":{"created_by":1,"id":"60826","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"60826"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00060826","sets":["10:29"]},"author_link":["603096","603105","603111","603098","603101","603100","603104","603107","603097","603108","603099","603106","603109","603113","603102","603112","603103","603110"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2004-11-20","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【目的】腹部臓器への炭素線治療では消化管障害が線量制限因子として重要である．\n我々は，今までにマウス小腸クリプト陰窩細胞生存率を指標にして炭素線分割照射効\n果を調べてきた．本研究では，サイトカインbFGFの関与について実験した結果を報告\nする．【方法】c3H雌マウスの腹部を炭素線20keV/micrometerで毎回1Gyを4時間間隔\nにて反復照射した．照射終了後に空腸を摘出し，坑bFGF抗体による免疫染色およびWe\nstern Blotを行った．また，一部の実験では，反復照射終了2時間目に坑bFGF抗体を\n静脈内投与し，その２時間後に線量を変化させるtop-up照射を行い，3.5日後空腸を\n摘出し，H.E.染色切片上のクリプト陰窩細胞を計測した．【成績】Western blotから\n判明したことは，（１）1 Gy3回照射目以降から12回目（最大反復照射回数）まででb\nFGFの発現が認められた，（２）最終反復照射後経時的にbFGF発現は減少したが，60\n時間目でも非照射群より高かった，（３）3回反復照射したマウスに投与した抗体は\n無効であったが，11回反復照射した後に抗体投与したマウスでは，腸管感受性が増大\nした．【結論】低LET炭素線照射で誘導されるbFGFが腸管を低感受性にしていること\nが示唆された．","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"日本放射線腫瘍学会大17回学術大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"鵜澤, 玲子"}],"nameIdentifiers":[{"nameIdentifier":"603096","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤, 興一"}],"nameIdentifiers":[{"nameIdentifier":"603097","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高井, 伸彦"}],"nameIdentifiers":[{"nameIdentifier":"603098","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"扶川, 武志"}],"nameIdentifiers":[{"nameIdentifier":"603099","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小池, 幸子"}],"nameIdentifiers":[{"nameIdentifier":"603100","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宮戸, 靖幸"}],"nameIdentifiers":[{"nameIdentifier":"603101","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木, 瑞穂"}],"nameIdentifiers":[{"nameIdentifier":"603102","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤, 佳也"}],"nameIdentifiers":[{"nameIdentifier":"603103","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平山, 亮一"}],"nameIdentifiers":[{"nameIdentifier":"603104","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鵜澤 玲子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"603105","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤 興一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"603106","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高井 伸彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"603107","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"扶川 武志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"603108","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小池 幸子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"603109","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宮戸 靖幸","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"603110","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木 瑞穂","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"603111","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤 佳也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"603112","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平山 亮一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"603113","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"炭素線照射で誘導される腸管感受性変化とbFGF発現の関係","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"炭素線照射で誘導される腸管感受性変化とbFGF発現の関係"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2005-02-02"},"publish_date":"2005-02-02","publish_status":"0","recid":"60826","relation_version_is_last":true,"title":["炭素線照射で誘導される腸管感受性変化とbFGF発現の関係"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:49:21.527310+00:00"}