{"created":"2023-05-15T14:44:24.117974+00:00","id":60708,"links":{},"metadata":{"_buckets":{"deposit":"ba93210e-2ede-4177-bb54-d1b18344ec5a"},"_deposit":{"created_by":1,"id":"60708","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"60708"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00060708","sets":["10:29"]},"author_link":["602072","602074","602076","602080","602081","602077","602082","602085","602083","602078","602071","602075","602073","602084","602070","602079"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2004-11-27","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Np95遺伝子破壊（ノックアウトNO）胚性幹（ES)細胞はX線、紫外線、MNNG、hydroxyureaに高感受性で、この核タンパクNP95がDNA損傷と複製停止に対する抵抗性の成立に関与することが判明した（JBC,277:34549,2002）。またこのKO-ES細胞では自然突然変異率が6TG抵抗性指標で対照の数十倍以上も高く、殆どが塩基置換であった。そこで放射線細胞致死に感受性が高いNp95-KO細胞の放射線誘発6TG抵抗性突然変異を調べた。さらにAprtヘテロ失活FM3A細胞にアンチセンスNp95cDNAを導入して、放射線誘発DAP抵抗性突然変異を対照細胞の場合と比較し、LDH成因の相同組換え（HR)、欠失（del）の寄与比率を調べ、NP95が関与するDNA代謝の役割と放射線誘発LOH型突然変異生成の関係についての示唆を得たい。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"日本放射線影響学会第47回大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"久保, ゑい子"}],"nameIdentifiers":[{"nameIdentifier":"602070","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"市川, 倫子"}],"nameIdentifiers":[{"nameIdentifier":"602071","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤森, ゆう子"}],"nameIdentifiers":[{"nameIdentifier":"602072","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤森, 亮"}],"nameIdentifiers":[{"nameIdentifier":"602073","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武藤, 正弘"}],"nameIdentifiers":[{"nameIdentifier":"602074","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高萩, 真彦"}],"nameIdentifiers":[{"nameIdentifier":"602075","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古野, 育子"}],"nameIdentifiers":[{"nameIdentifier":"602076","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"巽, 紘一"}],"nameIdentifiers":[{"nameIdentifier":"602077","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"久保 ゑい子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"602078","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"市川 倫子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"602079","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤森 ゆう子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"602080","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤森 亮","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"602081","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"武藤 正弘","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"602082","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高萩 真彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"602083","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福士 育子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"602084","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"巽 紘一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"602085","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"DNA損傷・複製停止に対する細胞の抵抗性を賦与する核タンパク質NP95と放射線誘発突然変異との関係","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"DNA損傷・複製停止に対する細胞の抵抗性を賦与する核タンパク質NP95と放射線誘発突然変異との関係"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2004-11-30"},"publish_date":"2004-11-30","publish_status":"0","recid":"60708","relation_version_is_last":true,"title":["DNA損傷・複製停止に対する細胞の抵抗性を賦与する核タンパク質NP95と放射線誘発突然変異との関係"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:50:41.802638+00:00"}