{"created":"2023-05-15T14:44:16.144370+00:00","id":60529,"links":{},"metadata":{"_buckets":{"deposit":"0f5c6175-0a01-4bde-b965-dc3fbe0ef08b"},"_deposit":{"created_by":1,"id":"60529","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"60529"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00060529","sets":["10:29"]},"author_link":["600656","600648","600651","600649","600653","600652","600655","600650","600647","600654"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2003-10-08","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"目的】放射線による第一義的損傷は，DNAに一粒子飛跡でおこるion killと二（多）粒子飛跡でおこるgamma killの双方がもたらす．本論文の目的は，治療効果比の高い炭素線治療とはどの様な分割法なのか，を明らかにすることである．【材料と方法】C3Hマウスと同系移植腫瘍NFSaを用いて，290MeV/u炭素線分割照射を行なった．雄マウス下肢皮下に移植した腫瘍径が７．５mmに達した時点で14,20,44,74 keV/mm炭素線にて24時間間隔で1乃至６分割照射した．照射後に照射時の腫瘍体積が５倍になるまでの日数を求め，この日数（TD time）が，対照群より１５日間長くなる線量を求めた．一方，皮膚についても炭素線（14,20,40,80 keV/micro.m）にて24時間間隔で1乃至６分割照射した．炭素線照射後皮膚反応を調べ，平均皮膚反応スコアーが3.0（乾性皮膚炎）になる線量を求めた．【結果】分割照射回数と炭素線RBEとの関係を腫瘍と皮膚について求めたところ，14と20 keV/micro.mでは両組織間で差はなく，1.2から1.7の間に分布していた．ブラッグピーク内のLET(腫瘍で44と74 keV/mm；皮膚で40と80 keV/mm) で照射した場合，42 keV/mm（腫瘍での44 keV/mmと皮膚での40 keV/mmとの平均値）では２乃至５分割照射の時に皮膚RBEは腫瘍RBEより小さくなっていた．これと同様なRBEの組織間違いは77 keV/micro.m（腫瘍での74 keV/mmと皮膚での80 keV/mmとの平均値）でも認められた．RBEは毎回照射線量が大きくなると減少した．14と20 keV/micro.mでは腫瘍と皮膚の間にRBEの差異はなかったが，42 と77 keV/micro.mでは腫瘍RBEの方が皮膚RBEよりも大きかった．Fe-plotにより求めたα値は，LETの増加とともに増大し，腫瘍と皮膚との間に差異はなかった．一方，皮膚のβ値はLETの増加とともに増大したが，腫瘍のβ値はLETと無関係であった．【結論】高LET放射線治療の有効性は大線量/分割で発揮されるはずである．","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第46回日本放射線影響学会大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"平山, 亮一"}],"nameIdentifiers":[{"nameIdentifier":"600647","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村山, 千恵子"}],"nameIdentifiers":[{"nameIdentifier":"600648","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤, 佳也"}],"nameIdentifiers":[{"nameIdentifier":"600649","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤, 興一"}],"nameIdentifiers":[{"nameIdentifier":"600650","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 敦"}],"nameIdentifiers":[{"nameIdentifier":"600651","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平山 亮一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"600652","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村山 千恵子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"600653","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤 佳也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"600654","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤 興一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"600655","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤 敦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"600656","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"低酸素下における重粒子線誘発酸化的DNA損傷のLET依存性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"低酸素下における重粒子線誘発酸化的DNA損傷のLET依存性"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2004-09-08"},"publish_date":"2004-09-08","publish_status":"0","recid":"60529","relation_version_is_last":true,"title":["低酸素下における重粒子線誘発酸化的DNA損傷のLET依存性"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:52:45.033210+00:00"}