{"created":"2023-05-15T14:44:16.007409+00:00","id":60526,"links":{},"metadata":{"_buckets":{"deposit":"7e0ee3f5-4d1f-465c-ae6d-5f81d2223d32"},"_deposit":{"created_by":1,"id":"60526","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"60526"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00060526","sets":["10:29"]},"author_link":["600632","600633"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2004-08-27","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"(Purpose) Carbon-ion therapy using HIMAC synchrotron started at Year 1994, and treated more than 1,800 patients by Year 2004.   Therapeutic outcome of this new modality is well recognized so that Japanese government approved our institute December 2003 to charge the treatment fee from patients.   Biology of heavy ions in past has attracted only limited number of basic scientists, but is now becoming a general topics in all oncology  areas.   I here shortly report experimental results and also biological analysis of clinical data that have been obtained recently.   (Materials and Methods) 1. in vitro experiments: 10 cell lines of  human melanoma (MM) and 11 cell lines of human squamous cell carcinoma (SCC) were cultured.   These cells were exposed to either carbon ions of 50 keV/micrometer or reference 200 kVp X rays.  Colony formation assay was carried out to obtain survival curves.   2. in vivo experiments: C3H/HeMsNrsf mice aged 12-18 weeks were used: males for the tumor study and females for the skin study.   The tumor was a syngeneic NFSa fibrosarcoma, and its 16 through 18th generations were transplanted intramuscularly into the right hind legs of mice 7 days before the first irradiation.    Hairs on the right hind leg of female mice were removed by applying a depilatory agent 7 to 8 days before the first irradiation.  A total of 881 male mice for the tumor experiment and of 2,323 female mice for the skin reaction experiment were used with 5 mice for each irradiation dose point.   All of the data collected from repeated experiments were combined.   3. Clinical data analysis: Local control rates of non-small cell lung cancer (NSCLC) by carbon-ion therapy were achieved by a treatment schedule of 18 fractions in 6 weeks with dose escalation.   Local control rates for photon therapy that were obtained other institutions were used to compare with those for carbon-ion therapy. (Results and Discussion) Survival parameters such as SF2 and D10 were plotted for X rays and carbon ions.   No difference between the two cell lines was obtained except alpha/beta ratio, which distribution was wider for SCC than MM after X-ray irradiation.   For carbon ions, the distribution was wider for MM than SCC.   RBE values of carbon ions  for tumor growth delay  was higher than RBE values for early skin reaction after high LET carbon ions, implying therapeutic gain of carbon ions even for early reaction.   Tumor control probabilities of NSCLC were analyzed by using alpha and beta values of a cultured human salivary gland tumor, HSG.   We found that the slope of TCP for carbon ions was steeper than that for photons.   This strongly support an concept that high LET radiation could overcome photon-resistant tumors that are heterogeneously  included in spontaneous human tumors.","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"The 33rd Annual Meeting of the European Society for Radiation Biology","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ando, Koichi"}],"nameIdentifiers":[{"nameIdentifier":"600632","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤 興一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"600633","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Experimental and Clinical Biology of Carbon-ion Therapy at HIMAC; an overview","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Experimental and Clinical Biology of Carbon-ion Therapy at HIMAC; an overview"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2004-09-03"},"publish_date":"2004-09-03","publish_status":"0","recid":"60526","relation_version_is_last":true,"title":["Experimental and Clinical Biology of Carbon-ion Therapy at HIMAC; an overview"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:52:47.061788+00:00"}