@misc{oai:repo.qst.go.jp:00060394,
 author = {Bing, Wang and Murakami, Masahiro and Eguchi-Kasai, Kiyomi and Nojima, Kumie and Shang, Yi and Tanaka, Kaoru and Fujita, Kazuko and Herve, Coffigny and Hayata, Isamu and 王 冰 and 村上 正弘 and 笠井 清美 and 野島 久美恵 and 尚 奕 and 田中 薫 and 藤田 和子 and 早田 勇},
 month = {May},
 note = {EFFECTS OF PRENATAL IRRADIATION OF ACCELERATED HEAVY ION BEAM ON POSTNATAL DEVELOPMENT IN RATS: I. NEUROPHYSILOGIC ALTERATIONS.
\nB. WANG*, M. MURAKAMI, K. EGUCHI-KASAI, K. NOJIMA, Y. SHANG, K. TANAKA, K. FUJITA, H. COFFIGNY, and I. HAYATA
Radiation Hazards Research Group, Radiation Safety Research Center,
National Institute of Radiological Sciences, Chiba 263-8555, Japan
*E-mail: jp2813km@nirs.go.jp
\nEffects on postnatal neurophysiological development in offspring were examined following exposure of pregnant Wistar rats to accelerated carbon ion beams with a LET value of about 13 keV/mm at a dose range from 0.1 Gy to 2.5Gy on the 15th day of gestation. The newborns were monitored for the age of appearance of 4 physiologic markers and of acquisition of 5 reflexes. Postnatal growth was monitored until postnatal 3 months. Offspring were timely autopsied to determine the presence of major organ alterations. Male offspring were evaluated as young adults using selected behavioral tests. Effects of X-rays estimated under the same biological endpoints were studied comparatively. For most of the endpoints at early age, significant alteration was not observed in offspring prenatally received 0.1 Gy irradiation of either accelerated carbon ion or X-rays compared to that from the sham-irradiated dams, while all offspring received 2.5 Gy died preweaningly. Offspring from dams irradiated with accelerated carbon ion generally showed higher incidences of prenatal death and preweaning mortality, markedly delayed accomplishment in their physiological markers and reflexes, and gain in body weight compared to that exposed to X-rays at doses of 0.5 to 2.0 Gy. Within this dose range, significantly reduced ratios of main organ weight to body weight at postnatal ages of 1, 2 and 3 months were also observed. Results indicated that irradiation of 0.5 to 2.0 Gy on the fetal age day 15 in rats dose-dependently caused permanent alterations in offspring including non-recuperable growth retardation, morphologic malformations in main organs, i.e., microcephaly, diminished reflex attainment, delayed appearance of physiologic markers, and changes in adult behavior. Such exposure to 1.0 to 2.0 Gy irradiation resulted in growth retardation and behavioural alterations persisting throughout life. The accelerated carbon ion generally induced higher detrimental effects compared to X-rays., 3rd International Workshop on Sapce Radiation Research},
 title = {Effects of prenatal irradiation of accelerated heavy ion beam on postnatal development in rats},
 year = {2004}
}