@misc{oai:repo.qst.go.jp:00060164, author = {Ohyama, Harumi and Bing, Wang and Yukawa, Osami and 大山 ハルミ and 王 冰 and 湯川 修身}, month = {Nov}, note = {High doses of ionizing radiation (HDR) induce a variety of harmful effects. However, low-doses radiation (LDR) can conditionally result in stimulatory effects in various cells and organisms. Radiation hormesis is defined as biopositive effects, such as augmentation of growth and survival, enhancement of immune response, suppression of mutagenesis and increase in resistance to the effects of further HDR. Adaptive response refers to LDR-induced resistance to the subsequent HDR. Radioadaptive response manifests a wide cross-resistance against oxidative damage from other stresses. In this presentation, first we would like to introduce briefly the dose effect relationship of ionizing radiation and then review the experimental, epidemiological and clinical data of radiation hormesis, with special emphasis on the studies conducted with whole-body irradiation. Second, we present our data clearly demonstrating radiation hormesis in the whole body irradiated animals. Living organisms have always lived in the presence of LDR. Radiation hormesis may be established at least in part evolutionarily as a cellular defense mechanism and thus have important biological significance and implications for health and disease. Research on radiation hormesis will indisputably contribute to elucidate aging process., 第7回アジア・オセアニア国際老年学会議}, title = {Radiation Hormesis: Stimulatory Effects of Low Doses Ionizing Radiation}, year = {2003} }