{"created":"2023-05-15T14:43:52.145995+00:00","id":60012,"links":{},"metadata":{"_buckets":{"deposit":"dfbd2545-ba3a-491a-a69a-cebff53730af"},"_deposit":{"created_by":1,"id":"60012","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"60012"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00060012","sets":["10:29"]},"author_link":["596823","596815","596824","596821","596813","596819","596827","596828","596818","596825","596820","596817","596816","596814","596826","596822"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2003-09-27","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【材料と方法】(1)C3H/HeMs、 C57BL/6Jマウス (2)5, 10, 20Gy にて胸部照射 (3)病理組織学的検討: HE 染色、マッソントリクローム染色 (4)免疫組織染色:線維化に関与する TGF-β,マクロファージの出現及び、肺組織障害に関わる CD44, ヒアルロン酸陽性細胞を評価 (5)トランスクリプトーム解析：cDNA マイクロアレイ (Agilent社)。 【結果】(1) 20Gy照射した場合にC57BL/6Jにおいてのみ肺線維症が観察された。 (2)TGF-β 陽性細胞は C3H/HeMs で照射後早期、C57BL/6J では晩期で出現し、CD44 陽性細胞は C3H/HeMsで多数出現し、系統差を認めた。 (3)発現比が2.0 以上の遺伝子は、約8300 の有効アレイスポット中約4〜11% であり、免疫関連遺伝子 IL18, S100a8, Cap1, Rad51ap1、組織修復関連遺伝子 MMP9などの発現誘導はC3H/HeMsではC57BL/6Jより明らかに高く、系統差があることを示した。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第６２回日本癌学会総会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"太田, 敏江"}],"nameIdentifiers":[{"nameIdentifier":"596813","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩川, 眞由美"}],"nameIdentifiers":[{"nameIdentifier":"596814","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野田, 秀平"}],"nameIdentifiers":[{"nameIdentifier":"596815","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"北沢, 知佐"}],"nameIdentifiers":[{"nameIdentifier":"596816","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"後藤, 美也子"}],"nameIdentifiers":[{"nameIdentifier":"596817","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中, 裕子"}],"nameIdentifiers":[{"nameIdentifier":"596818","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"原田, 良信"}],"nameIdentifiers":[{"nameIdentifier":"596819","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井, 高志"}],"nameIdentifiers":[{"nameIdentifier":"596820","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"太田 敏江","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"596821","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩川 眞由美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"596822","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野田 秀平","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"596823","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"北沢 知佐","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"596824","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中渡 美也子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"596825","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 裕子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"596826","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"原田 良信","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"596827","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今井 高志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"596828","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"放射線感受性の異なるマウス２系統を用いた胸部照射後肺障害の病理組織学的変化および遺伝子プロファイリング","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"放射線感受性の異なるマウス２系統を用いた胸部照射後肺障害の病理組織学的変化および遺伝子プロファイリング"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2003-10-08"},"publish_date":"2003-10-08","publish_status":"0","recid":"60012","relation_version_is_last":true,"title":["放射線感受性の異なるマウス２系統を用いた胸部照射後肺障害の病理組織学的変化および遺伝子プロファイリング"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:58:29.893093+00:00"}