@misc{oai:repo.qst.go.jp:00059934,
 author = {王, 冰 and 大山, ハルミ and 笠井, 清美 and 古澤, 佳也 and 尚, 奕 and 稲葉, 浩子 and 山田, 武 and 早田, 勇 and 王 冰 and 大山 ハルミ and 笠井 清美 and 古澤 佳也 and 尚 奕 and 稲葉 浩子 and 山田 武 and 早田 勇},
 month = {Apr},
 note = {We reported previously that Carbon ion beams and X-rays induced apoptosis in H5 and R223 cells. In both kinds of cells, irreversible reduction of transmembrane potential occurred earlier than chromatin condensation and DNA fragmentation, and cell shrinkage and death were observed in the later phase. Compared with X-rays, Carbon ion beams induced earlier and more effective depletion of transmembrane potential and other opoptotic changes in these cells. In the present study, examinations of caspase cascades in these apoptotic processes were performed using 7 kinds of cell permeable caspase inhibitors. Results revealed that the involvement of caspases in the induction of apoptosis by Carbon beams and X-rays was different. Further, the involvement of caspases was also related
to the cell type and the dosage of irradiation as well. These findings suggest that the order of downstream caspase actvation is dependent on both the apoptotic stimulus (irradiation source and dosage) and cell type., 平成15年度放射線医学総合研究所重粒子線がん治療装置等共同利用研究発表会},
 title = {リンパ腫細胞の重粒子線誘発アポトーシスの機構に関する研究},
 year = {2003}
}