{"created":"2023-05-15T14:43:23.714189+00:00","id":59441,"links":{},"metadata":{"_buckets":{"deposit":"76594987-9106-4e25-bd58-0efdfc96967b"},"_deposit":{"created_by":1,"id":"59441","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"59441"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00059441","sets":["10:29"]},"author_link":["591640","591642","591641","591645","591639","591638","591637","591646","591636","591647","591643","591648","591633","591634","591635","591649","591632","591644"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2002-09-20","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"放射線治療の際、分割照射によって治療可能比が改善される可能性がある。重粒子線の最適照射条件を検討するために、２分割照射の時間間隔を変え、マウス空腸の感受性の変化を観察した。２９０ MeV/uの炭素線（LET：２０keV/mm）での２分割照射（ 9Gy+topup）の際に、２回目の照射までの時間を、４，８，１２，２４，４８，７２，９６時間と変化させた。Ｘ線照射では、３時間の間隔でクリプトの放射線損傷は、ほぼ完全に回復すると言われているので、ここでは、４時間とした。照射３．５日後に屠殺したマウスから採取した空腸は、HE染色し、顕微鏡下でクリプト数のカウントを行った。照射間隔４時間の場合、生存曲線をみると１回照射のそれより抵抗性であった。しかし、時間間隔を８時間、１２時間と広げていくと、感受性が高くなった。２４〜９６時とさらに時間間隔を広げると生存曲線は、肩を示すようになった。次に、２回の照射線量を固定（１０Gy+5Gy）した際でも、４時間の時間間隔でいったんクリプト数の回復がみられるが、その後１２時間まではクリプト数の減少がみられた。この減少は、最初の照射によって同調した細胞集団が、より感受性の相に移行するためと考えられる。さらに時間間隔を長く（１８時間以上）すると再びクリプト数は増加し回復が認められたがこの回復は再増殖によるものと考えられる。以上のことから、２０keV/mm炭素線では、分割照射時間間隔が腸管クリプト生存率の決定に重要であることが判明した。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"第４５回大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"鵜澤, 玲子"}],"nameIdentifiers":[{"nameIdentifier":"591632","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小池, 幸子"}],"nameIdentifiers":[{"nameIdentifier":"591633","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤, 佳也"}],"nameIdentifiers":[{"nameIdentifier":"591634","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"扶川, 武志"}],"nameIdentifiers":[{"nameIdentifier":"591635","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木, 瑞穂"}],"nameIdentifiers":[{"nameIdentifier":"591636","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高井, 伸彦"}],"nameIdentifiers":[{"nameIdentifier":"591637","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"物部, 真奈美"}],"nameIdentifiers":[{"nameIdentifier":"591638","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宮戸, 靖幸"}],"nameIdentifiers":[{"nameIdentifier":"591639","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤, 興一"}],"nameIdentifiers":[{"nameIdentifier":"591640","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鵜澤 玲子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"591641","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小池 幸子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"591642","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤 佳也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"591643","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"扶川 武志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"591644","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木 瑞穂","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"591645","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高井 伸彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"591646","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"物部 真奈美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"591647","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宮戸 靖幸","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"591648","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤 興一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"591649","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"マウス腸管クリプトの炭素線感受性に及ぼす２分割照射時間間隔の影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マウス腸管クリプトの炭素線感受性に及ぼす２分割照射時間間隔の影響"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2002-11-15"},"publish_date":"2002-11-15","publish_status":"0","recid":"59441","relation_version_is_last":true,"title":["マウス腸管クリプトの炭素線感受性に及ぼす２分割照射時間間隔の影響"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T22:04:54.504520+00:00"}