@misc{oai:repo.qst.go.jp:00059355,
 author = {Grossi, Giafranco and Durante, Marco and Gialanella, G and Antonella, Pugliese Malia and Scampoli, P and Furusawa, Yoshiya and 古澤 佳也},
 month = {Oct},
 note = {Computer code calculations based on biophysical models are commonly used to evaluate the effectiveness of shielding in reducing the biological damage caused by cosmic radiation in space flights. Biological measurements are urgently needed to benchmark the codes. We have measured the induction of chromosomal aberrations in human peripheral blood lymphocytes exposed in vitro to 56Fe-ion beams accelerated at the HIMAC synchrotron in Chiba or at the AGS accelerator at the Brookhaven National Laboratories. Isolated lymphocytes were exposed to 500 or 1000 MeV/n iron beams (dose range 0.1 - 1 Gy) after traversal of 0 to 23 g/cm2 of PMMA (lucite, a common plastic material), Al, or Pb shielding. For comparison, cells were exposed to 200 MeV/n iron ions and to X-rays. Chromosomes were prematurely condensed by a phosphatase inhibitor (calyculin A) to avoid cell-cycle selection produced by the exposure to high-LET heavy-ion beams. Aberrations were scored in chromosomes 1, 2, and 4 following fluorescence in situ hybridization. The yield of chromosomal aberrations has been evaluated as a function of the dose at the sample position, and of the fluence of primary iron ions hitting the shield. The results prove that shielding can increase the effectiveness of heavy ions, and the damage is dependent upon shield thickness and material, and heavy ion energy and charge. Research project supported by the Italian Space Agency (ASI)., 34th COSPAR Scientific Assembly},
 title = {Chromosomal Aberrations Induced by High-Energy Iron Ions with Shielding},
 year = {2002}
}