{"created":"2023-05-15T14:43:15.364903+00:00","id":59259,"links":{},"metadata":{"_buckets":{"deposit":"9dd286ac-1cc6-4aa7-9a59-3a055b208442"},"_deposit":{"created_by":1,"id":"59259","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"59259"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00059259","sets":["10:29"]},"author_link":["589836","589834","589835","589837"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2001-10-31","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"DNA 二本鎖切断損傷の再結合修復過程におけるクロマチン構成因子の機能的な関与を、ヒト細胞核抽出画分を用いた試験管内再構成系を用いて調査した。その結果、一群の蛋白質によるDNA 二本鎖切断末端への協同的な凝集会合が、その反応特性を決定する重要な要件であることを見い出した。DNA 損傷構造への結合性ならびに特異な構造形成を促す活性画分を調製し、これより切断末端再結合反応に積極的に関わりうるクロマチン構成因子を複数分離、同定した。加えてそれら因子間の相互作用に関する予備的な知見を得た。これらのデータから推察される「比較的豊富な核内構造成分がDNA 損傷の生成を感知し、有効な catalytic reactions の前提として、repair-competent networksを編成する」という考えを示したい。","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"日本放射線影響学会第４４回大会","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高萩, 真彦"}],"nameIdentifiers":[{"nameIdentifier":"589834","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"巽, 紘一"}],"nameIdentifiers":[{"nameIdentifier":"589835","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高萩 真彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"589836","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"巽 紘一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"589837","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"DNA 二本鎖切断が介在する核蛋白質ネットワークの機能性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"DNA 二本鎖切断が介在する核蛋白質ネットワークの機能性"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2002-06-14"},"publish_date":"2002-06-14","publish_status":"0","recid":"59259","relation_version_is_last":true,"title":["DNA 二本鎖切断が介在する核蛋白質ネットワークの機能性"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T22:06:56.282523+00:00"}