@article{oai:repo.qst.go.jp:00058885,
 author = {鹿園, 直哉 and 森林, 健悟 and 鹿園 直哉 and 森林 健悟},
 journal = {Applications of laser-driven particle acceleration},
 month = {Jul},
 note = {The relevance and significance of clustered DNA damage, defined as two or more lesions formed within 1-2 helical turns of DNA by a single radiation track, to various biological effects are now widely accepted. However, it is still unknown how a given type of radiation, for example an ion particle, causes clustered DNA damage. Here, we describe our simulation results of very fast processes immediately following ion-irradiation, and the importance of unraveling the physical process immediately after ion particle irradiation. We suggest that laser-driven ion particles can be used to clarify the very fast physical process. Two possible pump-probe schemes for picosecond time-resolved measurements after laser-driven ion irradiation are discussed. First is time-domain THz spectroscopy, in which the effect of a heavy ion-induced strong electric field on the movement of polar molecular ions can be investigated. Second is the time-resolved x-ray small angle scattering technique (SAXS), in which the clustered molecules or holes generated in water could be detected. The very fast processes immediately following ion particle irradiation of water/cells remains an important area to be investigated in order to understand the underlying early stage mechanisms of ion-particle induced biological effects, particularly the formation of clustered DNA damage.},
 title = {Applications of laser-driven particle acceleration},
 year = {2018}
}