@article{oai:repo.qst.go.jp:00058831, author = {Matsumoto, Ken-ichiro and Hyodo, Fuminori and Anzai, Kazunori and Utsumi, Hideo and B., Mitchell James and C., Krishna Murali and 松本 謙一郎 and 安西 和紀 and 内海 英雄}, journal = {Brain redox imaging}, month = {Feb}, note = {Nitroxyl contrast agents (nitroxyl radicals, also known as nitroxide) are paramagnetic species, which can react with reactive oxygen species (ROS) to lose paramagnetism to be diamagnetic species. The paramagnetic nitroxyl radical forms can be detected by using electron paramagnetic resonance imaging (EPRI), Overhauser MRI (OMRI), or MRI. The time course of in vivo image intensity induced by paramagnetic redox-sensitive contrast agent can give tissue redox information, which is the so-called redox imaging technique. The redox imaging technique employing a blood–brain barrier permeable nitroxyl contrast agent can be applied to analyze the pathophysiological functions in the brain. A brief theory of redox imaging techniques is described, and applications of redox imaging techniques to brain are introduced.}, title = {Brain redox imaging}, year = {2011} }