{"created":"2023-05-15T14:42:53.419314+00:00","id":58767,"links":{},"metadata":{"_buckets":{"deposit":"5a6488db-ddf0-4934-b8c5-b75c0cb52ef3"},"_deposit":{"created_by":1,"id":"58767","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"58767"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00058767","sets":["11"]},"author_link":["586267","586268"],"item_10004_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"823","bibliographicPageStart":"819","bibliographicVolumeNumber":"69","bibliographic_titles":[{"bibliographic_title":"BRAIN and NERVE"}]}]},"item_10004_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"タウタンパクの凝集体病変を生体脳で可視化する技術は、認知症の超早期診断や、病態修飾治療に有用な情報をもたらしうる。タウの病的線維に結合する低分子薬剤が開発され、ポジトロン断層撮影（PET）によりタウ病変の画像化が可能になったが、その結果、(1) タウ凝集体は加齢に伴いアミロイドβ（Aβ）病理と独立して海馬体に蓄積する、(2) Aβ凝集体蓄積が引き金となり、タウ病変の蓄積部位は海馬体外へと拡大する、(3) タウ病変形成は、局所の神経細胞死と巣症状に密接に関連する、などの事柄が示された。一方で、非特異的結合の問題などを克服した次世代プローブが開発されている。タウPETなどのツールを活用し、タウ病態解明とタウを標的とする医薬品開発を目的に、柔軟な産学連携を実現するコンソーシアムの構築が、日本国内で進んでいる。","subitem_description_type":"Abstract"}]},"item_10004_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"医学書院"}]},"item_10004_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1881-6096","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"樋口, 真人"}],"nameIdentifiers":[{"nameIdentifier":"586267","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口 真人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"586268","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"タウPET","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"タウPET"}]},"item_type_id":"10004","owner":"1","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-07-24"},"publish_date":"2017-07-24","publish_status":"0","recid":"58767","relation_version_is_last":true,"title":["タウPET"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T22:12:24.357651+00:00"}