{"created":"2023-05-15T14:42:49.789395+00:00","id":58685,"links":{},"metadata":{"_buckets":{"deposit":"b9ae556f-bbd2-4b36-a3d3-35a9781165cc"},"_deposit":{"created_by":1,"id":"58685","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"58685"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00058685","sets":["11"]},"author_link":["585874","585873"],"item_10004_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"254","bibliographicPageStart":"241","bibliographicVolumeNumber":"51","bibliographic_titles":[{"bibliographic_title":"放射線生物研究"}]}]},"item_10004_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"　バイオドジメトリーは被災者から採取した生体試料を利用した被ばく線量評価法であり、0.5 Gyクラスの被ばく線量を高精度に推定することができる標準技術として染色体損傷解析法が既に実用化されている。一方で0.1 Gy前後の低線量被ばくに対応できるバイオドジメトリー技術は開発途上である。本稿では低線量被ばくへの応用の視点から近年のバイオドジメトリー研究の概要を総説する。また、筆者らが現在進めているRNAを指標とした低線量バイオドジメトリー技術について、定量性・再現性を確保するための注意事項を含め紹介する。この方法では高再現性かつ高精度な生体指標データが得られるので、低線量生物影響研究への活用も期待できる。\n\\nキーワード：DNA損傷-誘導遺伝子、発現RNA、定量RT-PCR、技術改良、線量依存性\n\\nBiodosimetry is dose-estimation technology using biological samples from the victims of radiation accident.  The chromosomal damage analysis has been established, and is considered as \"gold standard\" of biodosimetry to estimate absorbed doses of higher than 0.5 Gy of radiation.  On the other hand, biodosimetric technology for low absorbed dose around 0.1 Gy of radiation is now being developed.  In this article, studies on biodosimetry are reviewed and outlined from the viewpoint of low-dose radiation.  Additionally, our recent study of biodosimetry for the low absorbed dose of radiation using RNA indicator in the circulating blood from mice is described with the key points to obtain reproducible quantitative data in the experiments.  The advanced biodosimetric method with more precision and high reproducibility, described in this article, would be useful to study the biological effects from low-dose radiation.  \n\\nKey words:  DNA damage-induced gene, RNA expression, quantitative RT-PCR, Improved method, dose-dependency","subitem_description_type":"Abstract"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石原, 弘"}],"nameIdentifiers":[{"nameIdentifier":"585873","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石原 弘","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"585874","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<総説>低線量被ばくによる生体影響を利用したバイオドジメトリー","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<総説>低線量被ばくによる生体影響を利用したバイオドジメトリー"}]},"item_type_id":"10004","owner":"1","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-02-15"},"publish_date":"2017-02-15","publish_status":"0","recid":"58685","relation_version_is_last":true,"title":["<総説>低線量被ばくによる生体影響を利用したバイオドジメトリー"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T22:13:20.127724+00:00"}