{"created":"2023-05-15T14:42:46.371462+00:00","id":58608,"links":{},"metadata":{"_buckets":{"deposit":"dc3add7e-37ba-4b14-b253-c311e9a279b8"},"_deposit":{"created_by":1,"id":"58608","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"58608"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00058608","sets":["11"]},"author_link":["585635","585634"],"item_10004_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"42","bibliographicPageStart":"38","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"BIO Clinica"}]}]},"item_10004_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"神経変性型認知症の中核病理は、アミロイドβペプチド（Aβ）、タウタンパク、α-シヌクレイン、TDP-43などの病的タンパク凝集体が脳内に蓄積することであり、これらは神経変性と密接に関わることから、診断および治療の標的となりうる。Aβおよびタウの病変は、特異的に結合する放射薬剤を体内診断薬として、ポジトロン断層撮影（PET）による生体脳での可視化が近年実現している。治療薬評価におけるこれらのイメージング技術の有用性については、病態の疾患ごと、個人ごとの多様性を考慮した上で検討を重ねる必要がある。","subitem_description_type":"Abstract"}]},"item_10004_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"北隆館"}]},"item_10004_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0919-8237","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"樋口, 真人"}],"nameIdentifiers":[{"nameIdentifier":"585634","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口 真人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"585635","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"脳の可視化からみた認知症治療戦略","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脳の可視化からみた認知症治療戦略"}]},"item_type_id":"10004","owner":"1","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-03-17"},"publish_date":"2016-03-17","publish_status":"0","recid":"58608","relation_version_is_last":true,"title":["脳の可視化からみた認知症治療戦略"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T22:14:09.973191+00:00"}