{"created":"2023-05-15T14:42:45.182423+00:00","id":58581,"links":{},"metadata":{"_buckets":{"deposit":"644e63e8-abe7-422c-8d6e-adf1390b280d"},"_deposit":{"created_by":1,"id":"58581","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"58581"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00058581","sets":["11"]},"author_link":["585519","585518"],"item_10004_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-10","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{"bibliographic_title":"認知機能とカルシウム ー基礎と臨床ー"}]}]},"item_10004_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"1) アルツハイマー病に代表される神経変性型認知症では、アミロイドペプチド（amyloid-β：Aβ）やタウタンパクの凝集体が特徴的病変として脳内に蓄積する。\n2) 樹状突起スパインにおいて、Aβは代謝賦活型グルタミン酸受容体5型（metabotropic glutamate receptor type 5：mGluR5）のシナプスへの集簇を促し、タウはN-methyl-D-aspartate （NMDA）受容体のリン酸化を強めることが知られている。その結果、mGluR5とNMDA受容体の連結強化と神経細胞内へのカルシウム流入が生じる。\n3) mGluR5の集簇や、NMDA受容体との連結の変化は、mGluR5に特異的に結合する放射性リガンドを用いることで、ポジトロン断層撮影（positron emission tomography：PET）により画像化可能で、カルシウム恒常性破綻を反映するバイオマーカーがもたらされると見込まれる。\n4) 興奮性シナプス変性の病期に応じて、mGluR5やNMDA受容体を標的とする認知症治療薬が効果を発揮すると考えられ、どの薬剤をどのタイミングで用いるかを検討する際に、PETによる評価が有用となりうる。","subitem_description_type":"Abstract"}]},"item_10004_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"医薬ジャーナル社"}]},"item_10004_relation_10":{"attribute_name":"ISBN","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"978-4-7532-2760-0","subitem_relation_type_select":"ISBN"}}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"樋口, 真人"}],"nameIdentifiers":[{"nameIdentifier":"585518","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口 真人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"585519","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"認知機能とカルシウム ー基礎と臨床ー","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"認知機能とカルシウム ー基礎と臨床ー"}]},"item_type_id":"10004","owner":"1","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-09-28"},"publish_date":"2015-09-28","publish_status":"0","recid":"58581","relation_version_is_last":true,"title":["認知機能とカルシウム ー基礎と臨床ー"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T22:14:27.054410+00:00"}