{"created":"2023-05-15T14:42:41.830480+00:00","id":58505,"links":{},"metadata":{"_buckets":{"deposit":"adf20545-3a64-4dcd-a9d2-d2abe3ee75cc"},"_deposit":{"created_by":1,"id":"58505","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"58505"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00058505","sets":["11"]},"author_link":["585155","585156"],"item_10004_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"78","bibliographicPageStart":"71","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"CLINICAL CALCIUM"}]}]},"item_10004_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"アルツハイマー病に代表される神経変性型認知症では、アミロイドbetaペプチド（Abeta）やタウタンパクの凝集体が特徴的病変として脳内に蓄積する。樹状突起スパインにおいて、Abetaは代謝賦活型グルタミン酸受容体5型（mGluR5）のシナプスへの集簇を促し、タウはNMDA受容体のリン酸化を強めることが知られている。これらの変化の結果として、mGluR5とNMDA受容体の連結強化と神経細胞内へのカルシウム流入が生じる。mGluR5の集簇や、NMDA受容体との連結の変化は、mGluR5に特異的に結合する放射性リガンドをもちいることで、ポジトロン断層撮影（PET）により画像化可能で、カルシウム恒常性破綻を反映するバイオマーカーがもたらされると見込まれる。興奮性シナプス変性の病期に応じて、mGluR5やNMDA受容体を標的とする認知症治療薬が効果を発揮すると考えられ、どの薬剤をどのタイミングで用いるかを検討する際に、PETによる評価が有用となりうる。","subitem_description_type":"Abstract"}]},"item_10004_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"医薬ジャーナル社"}]},"item_10004_relation_10":{"attribute_name":"ISBN","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"978-4-7532-8598-3 C3047","subitem_relation_type_select":"ISBN"}}]},"item_10004_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0917-5857","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"樋口, 真人"}],"nameIdentifiers":[{"nameIdentifier":"585155","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"樋口 真人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"585156","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"分子神経イメージングとカルシウム","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"分子神経イメージングとカルシウム"}]},"item_type_id":"10004","owner":"1","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-02-02"},"publish_date":"2015-02-02","publish_status":"0","recid":"58505","relation_version_is_last":true,"title":["分子神経イメージングとカルシウム"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T22:15:13.809464+00:00"}