{"created":"2023-05-15T14:42:41.281731+00:00","id":58493,"links":{},"metadata":{"_buckets":{"deposit":"5eb09ce0-2232-4f5a-a38e-a69e61c1eb72"},"_deposit":{"created_by":1,"id":"58493","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"58493"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00058493","sets":["11"]},"author_link":["585100","585102","585106","585104","585099","585101","585103","585105"],"item_10004_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"726","bibliographicPageEnd":"27","bibliographicPageStart":"25","bibliographic_titles":[{"bibliographic_title":"ISOTOPE NEWS、726、25-27、2014"}]}]},"item_10004_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"最近、動物を用いた研究から、脳内のアルツハイマー病（AD）関連遺伝子の転写活性\nは低線量X線照射（0.1Gy）により変化したと報告され（Lowe et al., Radiat. Res., 171, 53-65, 2009）、新たな低線量放射線リスクとして大きな関心を呼んでいる。\n我々は、本報告を再検証し、低線量照射による認知機能やAD病理への影響を詳細に検\n討するため、マウスをX線（0.1Gy）または炭素線（0.05Gyまたは0.1Gy）で全身照射した後、\n海馬を採取し、AD関連遺伝子の発現を解析するとともに、学習や記憶機能はモーリス\n水迷路テストを用いて評価し、またアミロイドβペプチド（Aβ）の沈着をPETで評価した。\n更に、ADの病理学的変化はアミロイド前駆蛋白、Aβ、タウ蛋白並びにリン酸化タウ蛋\n白の免疫染色により評価する等、多面的な検討を実施した。その結果、低線量単回照\n射は、僅か数個のAD関連遺伝子に転写レベルの変化を誘導するが、認知機能やAD病理\nに有意な変化を起こすものではないとも結論を得て、J. Radiat. Res.誌およびJ.\nNeurosci. Res.誌に論文発表した。\n　アルツハイマー病発症にかかわる低線量放射線リスクについて、本研究によって、\n一定の（否定的）科学知見を提示したことはでき、社会的インパクトが高かった。","subitem_description_type":"Abstract"}]},"item_10004_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"（公益社団法人）日本アイソトープ協会"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田中, 薫"}],"nameIdentifiers":[{"nameIdentifier":"585099","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"季, 斌"}],"nameIdentifiers":[{"nameIdentifier":"585100","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王, 冰"}],"nameIdentifiers":[{"nameIdentifier":"585101","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"根井, 充"}],"nameIdentifiers":[{"nameIdentifier":"585102","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 薫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"585103","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"季 斌","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"585104","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"王 冰","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"585105","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"根井 充","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"585106","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"低線量放射線被ばくと認知症発症-マウスモデルでの検証-","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"低線量放射線被ばくと認知症発症-マウスモデルでの検証-"}]},"item_type_id":"10004","owner":"1","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-12-08"},"publish_date":"2014-12-08","publish_status":"0","recid":"58493","relation_version_is_last":true,"title":["低線量放射線被ばくと認知症発症-マウスモデルでの検証-"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T22:15:21.008603+00:00"}