{"created":"2023-05-15T14:42:13.878197+00:00","id":57887,"links":{},"metadata":{"_buckets":{"deposit":"978e6c1d-c45b-4a9e-abad-773853a02156"},"_deposit":{"created_by":1,"id":"57887","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"57887"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00057887","sets":["11"]},"author_link":["582337","582336","582335"],"item_10004_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"58","bibliographicPageStart":"53","bibliographicVolumeNumber":"18","bibliographic_titles":[{"bibliographic_title":"Hormone Frontier in Gynecology"}]}]},"item_10004_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"受精直後の受精卵には卵母細胞由来のmRNAやタンパク質などの母性因子の多くが残っているが、その後急速に分解される。オートファジーは細胞質の一部を取り囲んでリソソームで分解するシステムである。最近、筆者らはオートファジーが受精後に活発に起こることを見いだした。実際に、オートファジーに必須な遺伝子Atg5を欠損した受精卵は、着床前の４〜８細胞期に致死となることが明らかとなった。受精卵が正常に発生するためには、オートファジーによる母性因子の積極的な分解が不可欠であることを示唆している。","subitem_description_type":"Abstract"}]},"item_10004_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1340-220X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"塚本, 智史"}],"nameIdentifiers":[{"nameIdentifier":"582335","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"水島, 昇"}],"nameIdentifiers":[{"nameIdentifier":"582336","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"塚本 智史","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"582337","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"オートファジーの受精卵発生における役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"オートファジーの受精卵発生における役割"}]},"item_type_id":"10004","owner":"1","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-04-12"},"publish_date":"2011-04-12","publish_status":"0","recid":"57887","relation_version_is_last":true,"title":["オートファジーの受精卵発生における役割"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T22:22:07.721555+00:00"}