{"created":"2023-05-15T14:41:58.360683+00:00","id":57539,"links":{},"metadata":{"_buckets":{"deposit":"80739864-8407-4582-9def-75b691d7719f"},"_deposit":{"created_by":1,"id":"57539","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"57539"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00057539","sets":["11"]},"author_link":["580570","580573","580572","580571"],"item_10004_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"176","bibliographicPageStart":"171","bibliographicVolumeNumber":"51","bibliographic_titles":[{"bibliographic_title":"精神医学"}]}]},"item_10004_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"これまでの薬理学的研究ではin vitroでの受容体やトランスポーターへの親和性、モデル動物を用いた動物実験による行動学的観察などから、投与量が推定されていた。また、投与方法に関しても、薬物血中動態を指標に行われてきた。しかし、前者に関しては種差や生体条件との差異の影響が考えられ、さらには、モデル動物が実際の疾患を反映しているかという問題があった。さらに、血中薬物濃度は必ずしも標的臓器での薬物動態を反映していない可能性が指摘されている。PET（positron emission tomography)では、薬物の標的部位である受容体やトランスポーターに特異けk都合する物資をポジトロン各種で標識した、放射性リガンドを投与し、実際の生体内での受容体やトランスポーターの分布を測定することが可能となる。この手法を用いられる様々な薬物の脳内での薬物動態が検討されている。","subitem_description_type":"Abstract"}]},"item_10004_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0488-1281","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"須原, 哲也"}],"nameIdentifiers":[{"nameIdentifier":"580570","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荒川, 亮介"}],"nameIdentifiers":[{"nameIdentifier":"580571","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須原 哲也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"580572","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荒川 亮介","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"580573","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"統合失調症の治療：分子イメージングで探る合理的薬物療法","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"統合失調症の治療：分子イメージングで探る合理的薬物療法"}]},"item_type_id":"10004","owner":"1","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-02-19"},"publish_date":"2009-02-19","publish_status":"0","recid":"57539","relation_version_is_last":true,"title":["統合失調症の治療：分子イメージングで探る合理的薬物療法"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T22:26:00.261857+00:00"}