{"created":"2023-05-15T14:41:42.832086+00:00","id":57190,"links":{},"metadata":{"_buckets":{"deposit":"b2d1c085-86e7-440d-8861-fd9981a6dc1b"},"_deposit":{"created_by":1,"id":"57190","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"57190"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00057190","sets":["11"]},"author_link":["578821","578816","578815","578818","578819","578817","578820"],"item_10004_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"110","bibliographicPageStart":"101","bibliographicVolumeNumber":"27","bibliographic_titles":[{"bibliographic_title":"環境変異原研究"}]}]},"item_10004_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Oxygen radicals are produced through normal cellular metabolism, and formation of such radicals is further\nenhanced by ionizing radiation and by various chemicals. Among various classes of oxidative DNA damage,\n8-oxo-7,8-dihydroguanine (8-oxoG) is the most abundant, and appears to play important roles in mutagenesis\nand carcinogenesis. Enzymatic activities that may be responsible for preventing 8-oxoG-evoked\nmutations were identified in mammalian cells. We have focused on following the two enzymes. MTH1\n(Mth1) protein is the mammalian counterpart of E. coli MutT protein, which hydrolyzes 8-oxo-dGTP to its\nmonophosphate form in the nucleotide pool, thereby preventing the incorporation of the mutagenic substrate\ninto DNA. On the other hand, MUTYH (Mutyh) protein, a counterpart of E. coli MutY protein, having\nadenine/2-hydroxyadenine DNA glycosylase activity, is expected to prevent G:C to T:A transversions, by\nexcising adenine from G:A mismatches induced by 8-oxoG and 2-OH-A. To analyze the function of the mammalian\nMth1 and Mutyh proteins in vivo, we established gene-knockout mice for these two enzymes by gene\ntargeting, and investigated spontaneous tumorigenesis as well as mutagenesis. Here we discuss our recent\nprogress on spontaneous and oxidative stress-induced mutagenesis with these mutant mouse lines.","subitem_description_type":"Abstract"}]},"item_10004_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0910-0865","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"續, 輝久"}],"nameIdentifiers":[{"nameIdentifier":"578815","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山内, 一己"}],"nameIdentifiers":[{"nameIdentifier":"578816","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"磯田, 拓郎"}],"nameIdentifiers":[{"nameIdentifier":"578817","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"江頭, 明典"}],"nameIdentifiers":[{"nameIdentifier":"578818","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藏, 忍"}],"nameIdentifiers":[{"nameIdentifier":"578819","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中津, 可道"}],"nameIdentifiers":[{"nameIdentifier":"578820","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山内 一己","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"578821","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"酸化的DNA損傷誘発突然変異を回避する分子機構 ─DNA修復欠損マウスにおける突然変異と発がんの解析─","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"酸化的DNA損傷誘発突然変異を回避する分子機構 ─DNA修復欠損マウスにおける突然変異と発がんの解析─"}]},"item_type_id":"10004","owner":"1","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-09-29"},"publish_date":"2006-09-29","publish_status":"0","recid":"57190","relation_version_is_last":true,"title":["酸化的DNA損傷誘発突然変異を回避する分子機構 ─DNA修復欠損マウスにおける突然変異と発がんの解析─"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T22:29:50.956489+00:00"}