{"created":"2023-05-15T14:41:36.749817+00:00","id":57056,"links":{},"metadata":{"_buckets":{"deposit":"1562fb60-96ef-4c11-bee7-c3f645256b2f"},"_deposit":{"created_by":1,"id":"57056","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"57056"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00057056","sets":["11"]},"author_link":["578204","578211","578197","578199","578207","578215","578217","578202","578216","578208","578198","578210","578205","578214","578206","578209","578200","578203","578213","578201","578212"],"item_10004_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"170","bibliographicPageStart":"163","bibliographicVolumeNumber":"44","bibliographic_titles":[{"bibliographic_title":"放射線科学"}]}]},"item_10004_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"脳内コリン作動性神経系は、認知・記憶、運動制御、睡眠などに深く関与すると考えられている。Ｐｅｒｒｙらがアルツハイマー病（ＡＤ）の剖検脳を用いた研究で、コリンアセチルトランスフェラーゼ（ＣｈＡＴ）、アセチルコリンエステラーゼ（ＡＣｈＥ）、ブチリルコリンエステラーゼ（ＢＣｈＥ）などの酵素活性と痴呆の重症度の相関を示したように、実際、これまでアルツハイマー病（ＡＤ）、パーキンソン病（ＰＤ）、進行性核上性麻痺（ＰＳＰ）などの疾患における脳内コリン作動性神経系の機能低下が剖検脳を用いた研究で報告され、記憶障害、認知機能障害、運動機能障害との密接な関連が示唆されている1,10）。従来、これら脳内コリン作動性神経系機能マーカーをin vivoで測定する方法はなかったが、我々はかかる報告を踏まえ、in vivoでのヒト中枢コリン神経の変性を捉える方法について検討し、近年、図１に示すような、放射性炭素で標識したアセチルコリンアナログ、N-メチルピペリジン誘導体を開発し2,3,8)、ＰＥＴによる脳内ＡＣｈＥ活性の測定が可能となった。このうち、ヒトのＡＣｈＥへの特異性が９４％と高く4）、至適な反応速度をもつ［11Ｃ］Ｎーメチルピペリジルー４−アセテート（［11Ｃ］ＭＰ４Ａ）をトレーサーとして選択し、健常人およびＡＤなどの痴呆性疾患への臨床応用を行ってきた。本稿ではその方法論、痴呆性疾患における知見について概括したい。","subitem_description_type":"Abstract"}]},"item_10004_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0441-2540","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"黄田, 常嘉"}],"nameIdentifiers":[{"nameIdentifier":"578197","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"福士, 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