{"created":"2023-05-15T14:40:48.133687+00:00","id":55959,"links":{},"metadata":{"_buckets":{"deposit":"4456b58d-464e-470e-a180-1627aa9d5846"},"_deposit":{"created_by":1,"id":"55959","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"55959"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00055959","sets":["7"]},"author_link":["572593","572594","572591","572612","572600","572613","572609","572616","572589","572588","572608","572614","572597","572601","572592","572596","572617","572605","572611","572598","572602","572595","572615","572590","572606","572599","572604","572607","572603","572610"],"item_10004_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"NIRS-M-232","bibliographicPageStart":"74","bibliographicVolumeNumber":"第5回","bibliographic_titles":[{"bibliographic_title":"技術と安全の報告会報告集"}]}]},"item_10004_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"マウス、ラットのクローズドコロニー（閉鎖集団）は近交系とは異なり遺伝的多型性を有しており、それを長く保つため、近親交配を避け、ランダム交配である循環交配法が適用されている。近親交配が行われないことから、ある個体が持つ一個の劣性突然変異遺伝子は顕在化することなく、集団内に浮遊（drifting）している可能性がある。\nそこで我々は、CF1系マウスに内在する変異遺伝子を検索し、系統成立にいたる他のクローズドコロニーICR系、ddY系マウスとの相互の関連の推定およびヒト疾患モデル研究、放射線医・科学研究に有用な系統を作出することを目的に、平成１９年度に浜松医科大学医学部附属動物実験施設での技術研修で行った「クローズドコロニーマウス系統に内在する変異遺伝子の発掘と系統化」を平成２０年７月より当所にて継続作業したが、現在までに確認された種々の表現型の異常およびその家系集中性について報告する。","subitem_description_type":"Abstract"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata 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