{"created":"2023-05-15T14:40:45.163391+00:00","id":55892,"links":{},"metadata":{"_buckets":{"deposit":"3ff75989-afed-4a77-8b22-ad2c6c005e74"},"_deposit":{"created_by":1,"id":"55892","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"55892"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00055892","sets":["7"]},"author_link":["571934","571935","571927","571928","571926","571937","571938","571923","571925","571921","571922","571930","571932","571931","571933","571936","571924","571929","571939"],"item_10004_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-11","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"143","bibliographicPageStart":"142","bibliographic_titles":[{"bibliographic_title":"2010 Annual Report of the Research Project with Heavy Ions at NIRS-HIMAC"}]}]},"item_10004_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Abstract\nThe aim of this study is to clarify the effect of\ncarbon-ion beams (C-ions) for metastatic potential of malignant melanomas. B16/BL6 cells, a mouse malignant melanoma cell line having highly metastatic potential, were exposed to heavy-ion beams (C-ions) or photon beams (X-rays or γ-rays) in vitro or in vivo conditions. Survival curves showed higher cytotoxic effects of C-ions than X-rays. The abilities of migration, invasion and adhesion were significantly suppressed by C-ions with increment of dose and LET values, however a part of those abilities enhanced by X-rays at low dose range (0.5 - 1.0 Gy) compared with controls. Interestingly, the enhancement ratios for the metastatic potentials, migration, invasion and adhesion were higher than those for cell killing.\nLocal tumors implanted into right leg of mice (7.5± 0.5 mm) were irradiated with C-ions (290 MeV/u, 6cmSOBP) or γ-rays (137Cs). Lung metastatic nodules arise from local tumors was counted as metastasis after irradiation. The metastasis was suppressed by radiations depending on the physical dose, and the effect of C-ions was significant. Additionally, the surviving fraction of each cell in a tumor was obtained by in vivo-in vitro assay, and biological equivalent dose were estimated. C-ions also significantly suppressed metastatic fraction compared with γ-rays when the metastasis was re-analyzed using the equivalent dose. It might suggest that C-ion inhibit metastasis at radiotherapy compared with low-LET photons.","subitem_description_type":"Abstract"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松本, 孔貴"}],"nameIdentifiers":[{"nameIdentifier":"571921","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鵜澤, 玲子"}],"nameIdentifiers":[{"nameIdentifier":"571922","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平山, 亮一"}],"nameIdentifiers":[{"nameIdentifier":"571923","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小池, 幸子"}],"nameIdentifiers":[{"nameIdentifier":"571924","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鶴岡, 千鶴"}],"nameIdentifiers":[{"nameIdentifier":"571925","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"和田, 麻美"}],"nameIdentifiers":[{"nameIdentifier":"571926","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡安, 隆一"}],"nameIdentifiers":[{"nameIdentifier":"571927","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤, 興一"}],"nameIdentifiers":[{"nameIdentifier":"571928","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤, 佳也"}],"nameIdentifiers":[{"nameIdentifier":"571929","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"571930","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 孔貴","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"571931","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鵜澤 玲子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"571932","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平山 亮一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"571933","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小池 幸子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"571934","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鶴岡 千鶴","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"571935","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"和田 麻美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"571936","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡安 隆一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"571937","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤 興一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"571938","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤 佳也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"571939","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"転移に対する重粒子線の効果解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"転移に対する重粒子線の効果解析"}]},"item_type_id":"10004","owner":"1","path":["7"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-12-12"},"publish_date":"2013-12-12","publish_status":"0","recid":"55892","relation_version_is_last":true,"title":["転移に対する重粒子線の効果解析"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T22:44:10.780131+00:00"}