@article{oai:repo.qst.go.jp:00055892,
 author = {松本, 孔貴 and 鵜澤, 玲子 and 平山, 亮一 and 小池, 幸子 and 鶴岡, 千鶴 and 和田, 麻美 and 岡安, 隆一 and 安藤, 興一 and 古澤, 佳也 and et.al and 松本 孔貴 and 鵜澤 玲子 and 平山 亮一 and 小池 幸子 and 鶴岡 千鶴 and 和田 麻美 and 岡安 隆一 and 安藤 興一 and 古澤 佳也},
 journal = {2010 Annual Report of the Research Project with Heavy Ions at NIRS-HIMAC},
 month = {Nov},
 note = {Abstract
The aim of this study is to clarify the effect of
carbon-ion beams (C-ions) for metastatic potential of malignant melanomas. B16/BL6 cells, a mouse malignant melanoma cell line having highly metastatic potential, were exposed to heavy-ion beams (C-ions) or photon beams (X-rays or γ-rays) in vitro or in vivo conditions. Survival curves showed higher cytotoxic effects of C-ions than X-rays. The abilities of migration, invasion and adhesion were significantly suppressed by C-ions with increment of dose and LET values, however a part of those abilities enhanced by X-rays at low dose range (0.5 - 1.0 Gy) compared with controls. Interestingly, the enhancement ratios for the metastatic potentials, migration, invasion and adhesion were higher than those for cell killing.
Local tumors implanted into right leg of mice (7.5± 0.5 mm) were irradiated with C-ions (290 MeV/u, 6cmSOBP) or γ-rays (137Cs). Lung metastatic nodules arise from local tumors was counted as metastasis after irradiation. The metastasis was suppressed by radiations depending on the physical dose, and the effect of C-ions was significant. Additionally, the surviving fraction of each cell in a tumor was obtained by in vivo-in vitro assay, and biological equivalent dose were estimated. C-ions also significantly suppressed metastatic fraction compared with γ-rays when the metastasis was re-analyzed using the equivalent dose. It might suggest that C-ion inhibit metastasis at radiotherapy compared with low-LET photons.},
 pages = {142--143},
 title = {転移に対する重粒子線の効果解析},
 year = {2011}
}