@article{oai:repo.qst.go.jp:00055885,
 author = {遠藤, 悟史 and 藤田, 真由美 and 山田, 滋 and 今留, 香織 and 篠藤, 誠 and 今井, 高志 and 遠藤 悟史 and 藤田 真由美 and 山田 滋 and 今留 香織 and 篠藤 誠 and 今井 高志},
 issue = {HIMAC-138},
 journal = {放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書},
 month = {Nov},
 note = {On the clinical trial, it is often noticed that the lower dose of C-ion radiotherapy shows similar efficiency in lymph node compared to the higher dose of C-ion radiotherapy to the primary tumor indicated that lymph node metastasis may be more sensitive than the primary tumor. In order to characterize the primary tumor and lymph node metastasis site, and compare the efficiency of C-ion radiotherapy we used 2 types of human colon cancer cell lines established from the primary tumor (SW480) and the lymph node metastasis site (SW620) of the same patient for experiments; invasiveness, growth, and sensitivity to C-ion and X-ray irradiation. SW480 showed higher invasiveness with lower sensitivity to X-ray irradiation than SW620 cell line. X-ray irradiation resulted in only 50% reduction of SW480 invasiveness. On the other hand, C-ion more effectively blocked those invasiveness of SW480, and reduced colony formation number than X-ray irradiation, which relative biological efficiencyof D10 was 2.9. However in the comparison with SW620, SW480 was more resistant to C-ion infadiation. We further found that the AP-1 family of transcription factor (FRA-1) has role in different sensitivity to C-ion irradiation found between SW480 and SW620.},
 pages = {43--44},
 title = {放射線照射によるヒト大腸癌由来細胞株の浸潤能変化の検討},
 year = {2012}
}