@article{oai:repo.qst.go.jp:00055823,
 author = {森川, 貴迪 and 長谷川, 安都佐 and 小藤, 昌志 and 高木, 亮 and 森川 貴迪 and 長谷川 安都佐 and 小藤 昌志 and 高木 亮},
 issue = {HIMAC-138},
 journal = {放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書},
 month = {Aug},
 note = {Purpose: To analyze the association between the irradiation dose and the radiation-induced atrophy of the parotid gland after carbon ion radiotherapy(C-ion RT), using dose-volume histograms.
Material and methods: Between April 1997 and February 2008, 93 parotid glands of 54 patients whose normal parotid glands were included in the irradiation volume were analyzed. Patients had a minimum follow-up period of 2 years. The prescribed tumor dose was 57.6 GyE in 30 patients and 64.0 GyE in 24 patients. Median follow-up was 46.4 months. We measured the volume of parotid glands based on CT imaging before and after C-ion RT, and analyzed the relevant covariates.
Result: Mean volume of parotid glands before and after C-ion RT was 25.8ml, and 20.2ml. The mean volume change was -20.0%. The period of volume reduction was 6.9months. Univariate analysis for volume reduction showed that the significant variables were sex and percentage of volume of the parotid gland receiving more than 5GyE(V5). In multivariate analysis, only V5 was significantly associated with volume reduction.
Conclusions: The V5 of parotid gland has been identified as a relevant factor for volume reduction in C-ion RT. This result might provide important clue for optimizing the dose distribution in treatment planning.},
 pages = {7--8},
 title = {炭素イオン線治療における耳下腺の体積変化と線量の関わりの研究},
 year = {2012}
}