@article{oai:repo.qst.go.jp:00055585,
 author = {王, 旭飛 and 小西, 輝昭 and 濱野, 毅 and 安田, 仲宏 and 今関, 等 and 石川, 剛弘 and 磯, 浩之 and 酢屋, 徳啓 and 湯川, 雅枝 and 王 旭飛 and 小西 輝昭 and 濱野 毅 and 安田 仲宏 and 今関 等 and 石川 剛弘 and 磯 浩之 and 酢屋 徳啓 and 湯川 雅枝},
 issue = {NIRS-M-205},
 journal = {放射線医学総合研究所技術報告書},
 month = {Oct},
 note = {The Single Particle Irradiation to Cells (SPICE) facility has been constructed for biological cell irradiation, with the ability to deliver precisely defined numbers of ions to a small region within the area of an individual living cell. SPICE is able to provide 3.4 MeV proton and 5.1 MeV alpha particle microbeams using a mono-bloc triplet quadrupole lens (Q lens), located just prior to beam exit. We are currently adopting a scintillation counter that detects ions after passing through a biological cell, and a pair of electrostatic beam deflecting plates to realize single-ion irradiation, and a high speed (100 mum / 20 msec) stage as target mover. The output signal of the counter is fed to a computer-based scaler, and then a high voltage is applied for the deflecting plates to deflect the beam, once a defined number of protons has detected. The dosage precision of the single particle irradiation system has been tested for 3.4 MeV protons using a thin CR-39 detector. The statistics of the etched pits number on the CR-39 has demonstrated that the single-ion irradiation system is capable of quantitative irradiation with the efficiency (the probability of which the number of traversal ion is equal to the preset value) measured to be 95.1  % at high speed irradiation (50 positioning / sec).},
 pages = {8--13},
 title = {Development of single particle microbeam irradiation system for radiation biology},
 volume = {2007},
 year = {2007}
}