@article{oai:repo.qst.go.jp:00055573,
 author = {岩川, 眞由美 and 野尻, 和典 and 田巻, 倫明 and 今留, 香織 and 酒井, 美奈子 and 今井, 高志 and 岩川 眞由美 and 野尻 和典 and 田巻 倫明 and 今留 香織 and 酒井 美奈子 and 今井 高志},
 issue = {HAIMAC-125},
 journal = {放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書},
 month = {Jun},
 note = {To identify molecular mechanism of effectiveness induced by carbon-ion radiotherapy, we investigated expression profiles of murine tumors, which varied its radiosensitivity to gamma irradiation, using microarrays consisting of 55K genes. Six murine tumors (squamous cell carcinoma: NR-S1, SCCVII, Fibrosarcoma: NFSa, #8520, and Mammary carcinoma: MCa#4, MMCa) were transplanted in hind legs of C3H/Henirs mice and solid tumors were irradiated with either carbon-ion beam or 
gamma-ray. In microarray analysis, the pairwise comparisons between pre-treatment sample and post-treatment sample at 6h, 1 day, and 3 day after irradiation in each tumor were made by Wilcoxon test. We detected several tens of genes, whose expressions were significantly changed after carbon-irradiation. These genes were ontologically categorized into cell-cycle and immune response. Furthermore, comparison of expression intensity between 
radiosensitive (SCC-VII) and radioresistant (NR-S1) tumors by ANOVA test revealed a candidate molecule to be related with radioresistance.},
 pages = {100--101},
 title = {マウス腫瘍の重粒子線照射効果関連遺伝子群の網羅的解析},
 volume = {NIRS-M-203},
 year = {2007}
}