@article{oai:repo.qst.go.jp:00055449,
 author = {加藤, 博敏 and 辻井, 博彦 and 溝江, 純悦 and 神立, 進 and 江澤, 英史 and 小畠, 隆行 and 大藤, 正雄 and 加藤 博敏 and 辻井 博彦 and 溝江 純悦 and 神立 進 and 江澤 英史 and 小畠 隆行 and 大藤 正雄},
 issue = {HIMAC-069},
 journal = {放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書},
 month = {Apr},
 note = {We performed Contrast-Enhanced 3D Ultrasonography (CE-Fusuion 3D) o 22 patients with hepatocellular carcinoma (HCC) (40mm or less in diameter) and 5 with metastatic liver cancer to obtain the specific features of HCC. We recognized Network Pattern and Flush Sign as characteristic features of HCC in CE-Fusion 3D, which were thought to be contrast-enhanced vascular images. None of these features were detected in the metastatic liver cancers. All the five HCCs 15mm or less in diameter had both features. 3 (60%) of which had early staining and 2 (40%) had late washout in the contrast-enhanced CT scan with bolus injection of a contrast agent. 
 We also performed CE-Fusion 3D on 46 patients with HCC (40mm or less in diameter) to investigate the invasively-growing lesion of HCC. All the invasively-Growing lesions of HCC had the Network Pattern and the Flush Sign. It was more easily to detect such lesions by CE-Fusion 3D rather than non-enhanced 2D or 3D US. Twenty-three of all the 37 HCCs (62%) 15mm or more in diameter had the invasively-growing lesions, but no HCCs less than 15mm in diameter had them.
 In conclusion, CE-Fusion 3D may allow the diagnosis of HCC and its invasively-growing lesion by such characteristic features as Network Pattern and Flush Sign, and it may be superior to the contrast-enhanced CT scan in such a diagnostic efficiency.},
 pages = {5--8},
 title = {肝癌の重粒子線治療における非侵襲的治療効果判定法に関する研究},
 year = {2003}
}