{"created":"2023-05-15T14:40:15.549969+00:00","id":55241,"links":{},"metadata":{"_buckets":{"deposit":"f29b91dd-76c5-4523-81ab-2682c76ccc30"},"_deposit":{"created_by":1,"id":"55241","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"55241"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00055241","sets":["7"]},"author_link":["565047","565048","565040","565041","565049","565053","565051","565054","565055","565052","565043","565044","565050","565045","565046","565042"],"item_10004_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-04","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"114","bibliographicPageStart":"113","bibliographicVolumeNumber":"2002","bibliographic_titles":[{"bibliographic_title":"放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書"}]}]},"item_10004_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"HeLa cells were irradiated with Fe ions (specific energy: 0.93 MeV/u, LET: 4.79 MeV/um3) at the Medium Energy Beam Course. Irradiated cells were immuno-stained with gamma-H2AX antibody to visualize the distribution of DNA double strand break (dsb), which specifically induces phosphorylation of H2AX (gamma-H2AX). In an irradiated cell, bright and well-defined fluorescent foci were seen in the nucleus, but in a non-irradiated cell, no or few foci were detected. Cross-sectional views that were constructed with the software using 20 sliced images of a nucleus with 0.55 um interval, showed rod-like shapes of green fluorescence from top to bottom of the nucleus. These must be cross-sectional images of the gamma-H2AX column produced by ions traversing the nucleus. The correlation between the number of gamma-H2AX foci observed and average number of ion traversals through a nucleus showed 0.92 +/- 0.09. This proves that the foci of gamma-H2AX, were produced at each ion traversal.","subitem_description_type":"Abstract"}]},"item_10004_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"放医研"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小西, 輝昭"}],"nameIdentifiers":[{"nameIdentifier":"565040","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"竹安, 明浩"}],"nameIdentifiers":[{"nameIdentifier":"565041","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石澤, 紗智"}],"nameIdentifiers":[{"nameIdentifier":"565042","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山浦, 晋"}],"nameIdentifiers":[{"nameIdentifier":"565043","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"檜枝, 光太郎"}],"nameIdentifiers":[{"nameIdentifier":"565044","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤, 幸夫"}],"nameIdentifiers":[{"nameIdentifier":"565045","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安田, 仲宏"}],"nameIdentifiers":[{"nameIdentifier":"565046","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤, 佳也"}],"nameIdentifiers":[{"nameIdentifier":"565047","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小西 輝昭","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"565048","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"竹安 明弘","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"565049","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石澤 紗智","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"565050","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山浦 晋","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"565051","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"檜枝 光太郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"565052","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐藤 幸夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"565053","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安田 仲宏","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"565054","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤 佳也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"565055","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ブラッグピーク近傍の重粒子イオンを用いたイオン特異的なＤＮＡ損傷の誘発と修復","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ブラッグピーク近傍の重粒子イオンを用いたイオン特異的なＤＮＡ損傷の誘発と修復"}]},"item_type_id":"10004","owner":"1","path":["7"],"pubdate":{"attribute_name":"公開日","attribute_value":"2004-01-25"},"publish_date":"2004-01-25","publish_status":"0","recid":"55241","relation_version_is_last":true,"title":["ブラッグピーク近傍の重粒子イオンを用いたイオン特異的なＤＮＡ損傷の誘発と修復"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T22:51:48.167446+00:00"}