@article{oai:repo.qst.go.jp:00055143,
 author = {吉岡, 公一郎 and 田中, 越郎 and 藤倉, 寿則 and 杉尾, 芳紀 and 篠崎, 芳郎 and 笠原, 啓史 and 石過, 孝文 and 佐藤, 江利子 and 盛, 英三 and 古澤, 佳也 and 吉岡 公一郎 and 藤倉 寿則 and 盛 英三 and 古澤 佳也},
 journal = {放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書},
 month = {Apr},
 note = {Heterogeneities in sympathetic denervation and in myocardial blood flow are thought to be substrates of lethal ventricular arrhythmia. It cannot be fully treated even by a catheter ablation. We evaluated whether heavy ion beam could be applied to anti-arrhythmic therapy. The left chest (20x20 mm) was irradiated by a single dose (90Gy) of heavy ion beam (290MeV/u carbon-12). We created chronic myocardial ischemia by injecting microspheres (15 um in diameter) into the coronary artery in four rabbits. Two weeks after making ischemia, irradiation was performed as above in two ischemia rabbits. One month after the irradiation, program-induced VT/VF were completely suppressed. In two non-irradiated ones, however, VT/VF were induced by programmed stimulation easily. These results suggest that irradiation of heavy ion beam to the subepicardial region is applicable to the anti-arrhythmic therapy due to homogenous sympathetic denervation without deterioration in local blood flow and contraction.},
 pages = {169--170},
 title = {重粒子線を用いた根治的不整脈治療の開発},
 volume = {2002},
 year = {2002}
}