@article{oai:repo.qst.go.jp:00055142,
 author = {安藤, 興一 and 小池, 幸子 and 古澤, 佳也 and 鵜澤, 玲子 and 青木, 瑞穂 and 扶川, 武志 and 高井, 伸彦 and 物部, 真奈美 and 宮戸, 靖幸 and 金井, 達明 and 小森, 雅孝 and 松藤, 成弘 and 安藤 興一 and 小池 幸子 and 古澤 佳也 and 鵜澤 玲子 and 青木 瑞穂 and 扶川 武志 and 高井 伸彦 and 物部 真奈美 and 宮戸 靖幸 and 金井 達明 and 小森 雅孝 and 松藤 成弘},
 journal = {放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書},
 month = {Apr},
 note = {The purpose of this study is to compare the biological effectiveness of light ions and heavy ions for tumors of which therapeutic gain of carbon ions is relatively low. Carbon ions has been used to treat more than 1000 patients in our institute. One of the tumors responding well to carbon ions is malignant melanomas while squamous cell carcinomas show response comparable to photon radiotherapy. It is possible that the two types of tumors, i.e., malignant melanoma and squamous cell carcinoma, are different in radiosensitivity to carbon ions, provided that the clinical difference between the two tumors is due to any biological reasons. We assumed two possibilities to reason the biological difference between the tumors. First, malignant melanomas in general are more resistant to photons than squamous cell carcinomas while relative biological effectiveness (RBE) of carbon ions are the same between the two tumors. In this case, biological factor(s) that determine radiosensitivities of tumors are independent of radiation qualities. Second, malignant melanomas respond better than squamous cell carcinomas such that RBE of carbon ions are larger for malignant melanomas than squamous cell carcinomas. We will use 10 malignant melanomas and 10 squamous cell carcinomas of human origin, and compare radiosensitivities of each cell line in vitro and in vivo. The ions we use here are both lighter and heavier than carbon ions. In our previous studies of carbon ions, intermediate LET is not only superior to low LET but also more than comparable to high LET in achieving the biological therapeutic gain that is calculated by comparing RBE values between mice skin reaction scoring and tumor growth delay. We have here measured physical characteristics of two ions, i.e., helium-4 and argon-40, and will use the two beams to compare biological effectiveness between the two tumors.},
 pages = {166--168},
 title = {次期治療ビームに関する研究},
 volume = {2002},
 year = {2002}
}