@article{oai:repo.qst.go.jp:00055127,
 author = {大西, 武雄 and 高橋, 昭久 and 浅川, 勇雄 and 大西, 健 and 玉本, 哲朗 and 古澤, 佳也 and 大西 武雄 and 高橋 昭久 and 浅川 勇雄 and 大西 健 and 玉本 哲郎 and 古澤 佳也},
 journal = {放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書},
 month = {Apr},
 note = {To investigate the dependency of p53 gene status on the thermal enhancement of cellular sensitivity against different levels of linear energy transfer (LET) of X-rays or carbon-ion (C-) beams. We found that (i) there was no significant difference in sensitivity to high LET radiation of above 30 KeV/um between SAS/neo and SAS/mp53 cells, although the radiosensitivity of SAS/neo cells against X-rays was higher (1.2-fold) than that of SAS/mp53 cells; (ii) there was an interactive thermal enhancement of radiosensitivity to below 70 KeV/um in SAS/neo cells, although only additive thermal enhancement of them was observed in SAS/mp53 cells through all LET levels examined; (iii) low-LET radiation induced apoptosis only in SAS/neo cells; (iv) high-LET radiation at an iso-survival dose induced apoptosis of SAS/neo cells at a high frequency compared with that with low-LET radiation; (v) high-LET radiation induced p53-independent apoptosis in SAS/mp53 cells; (vi) thermal enhancement of cellular sensitivity against X-ray was due to induction of the p53-dependent apoptosis. Our findings suggest that thermal enhancement of radiosensitivity may be resulted in p53-dependent apoptosis instead of inhibition of p53-dependent cell survival system(s) through either regulation of the cell cycle or induction of DNA repair.},
 pages = {49--50},
 title = {癌関連遺伝子からみた重粒子線治療の基礎的研究},
 volume = {2002},
 year = {2002}
}