@article{oai:repo.qst.go.jp:00055118,
 author = {山田, 滋 and 李, 玲華 and デュランテ, マルコ and 宮本, 忠昭 and 山本, 直敬 and 川田, 哲也 and 中野, 隆史 and 安藤, 興一 and 古澤, 佳也 and 馬嶋, 秀行 and 辻井, 博彦 and 山田 滋 and 李 玲華 and 宮本 忠昭 and 山本 直敬 and 川田 哲也 and 中野 隆史 and 安藤 興一 and 古澤 佳也 and 馬嶋 秀行 and 辻井 博彦},
 journal = {放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書},
 month = {Apr},
 note = {The purpose of this study is to investigate the normal tissue damage caused by X-ray or carbon-ion therapy. We measured chromosomal aberrations in peripheral blood lymphocytes before, during and after the radiation treatment by using the novel technique of Interphase Chromosome Painting. Premature chromosome condensation(PCC) was induced in stimulated lymphocytes by incubation in calyculin A, and slides were hybridized in situ with whole-chromosome DNA probes specific for human chromosome 2 and 4 (FISH). Chromosome aberrations decreased after the end of radiotherapy. The number of fragment which is one type of chromosome aberrations decreased after treatment, but the number of reciprocal exchange did not decreased. In lung cancer patients treated with carbon-ion, chromosome aberrations increased as tumor dose and were dependent on target volumes. These results suggest that Interphase Chromosome Painting (PCC+FISH) is an efficient tool for biodosimetry of radiation treatment.},
 pages = {25--26},
 title = {PCC+FISH 法を用いた新しい感受性試験の研究},
 volume = {2001},
 year = {2001}
}