@article{oai:repo.qst.go.jp:00055085,
 author = {坪内, 進 and 福津, 久美子 and 五日市, ひろみ and 村上, 正弘 and 古澤, 佳也 and 笠井, 清美 and 金井, 達明 and 小池, 幸子 and 安藤, 興一 and 河野, 明広 and 松下, 悟 and 大原, 弘 and 谷田貝, 文夫 and 加納, 永一 and 坪内 進 and 福津 久美子 and 五日市 ひろみ and 村上 正弘 and 古澤 佳也 and 笠井 清美 and 金井 達明 and 小池 幸子 and 安藤 興一 and 河野 明広 and 松下 悟 and 大原 弘 and 谷田貝 文夫},
 journal = {放射線医学総合研究所重粒子線がん治療装置等共同利用研究報告書},
 month = {Apr},
 note = {At this fiscal year, only three times irradiation experiments were performed to obtain RBE of heavy ions (carbon, neon, proton) for acute cell death of pancreatic islet cells in vivo.
Firs of all this project was designed to obtain RBE of 290MeV carbon and 400 MeV neon beams for acute cell death of pancreatic islets of golden hamster (Mesocricetus auratus) in the condition of in both in vivo and in vitro systems. As mentioned in previous report vitro system, however, resulted in ill success possibly in terms of physiological conditions. As the limited chance of experiments, this in vitro experiment was tentatively shelved for the time being. In return in vivo experiments for low LET region of neon beams (32.5keV/u) and carbon beams (15.0keV/u) were performed. These results together with those previously obtained for 200keV/ X-ray, 70MeV proton, 290MeV carbon (60keV/u), and neon (100keV/u) beams were reconsidered Dose response relations (25,50,100,150,and 200Gy respectively) in acute cell death of pancreatic islets studied histologically after whole body irradiation of 3 weeks young male golden hamster with lower LET carbon beams (15.0keV/u) and neon beams (32.5keV/u). Results indicated that Do of carbon beams (15.0keV/u) and neon beams (32.5keV/u) was 38Gy and 49Gy respectively.  Previously obtained D0 data for 200keV/ X-ray, 70MeV proton, 290MeV carbon (60keV/u) and neon (100keV/u) beams were 38Gy, 35-40Gy, 75Gy and 150-250Gy, respectively.  From these data estimated RBE of neon (100keV/u and 32.5keV/u), carbon (60keV/u and 15.0keV/u) and proton beams were 0.19-0.25, 0.76, 0.49, 0.97, respectively. Therefore the order of RBE (or radiosensitivities) of islets cells with these various heavy ion beams was dependent on the order of each LET value irrespective of beam species.},
 pages = {63--64},
 title = {急性膵島細胞死で見た重粒子線のRBE},
 volume = {2001},
 year = {2002}
}